Alcohol and other drug use are common in adolescence. Our prior studies found that adolescents with alcohol use disorders (AUD), and even binge drinking in the absence of a diagnosis, show abnormalities on indices of brain functioning, including neuropsychological test performance;hippocampal, prefrontal, and cerebellar volumes;white matter microstructural integrity;and functional magnetic resonance imaging (FMRI) response to cognitive and alcohol cue tasks. However, some of these indices are related to risk factors for adolescent alcohol involvement, such as family history of AUD. Thus, it is unclear if abnormalities observed in adolescent heavy drinkers are caused by alcohol exposure, or predated the onset of heavy drinking. Description: This renewal project will follow 296 youth previously characterized in R01 AA13419 prior to the onset of substance use. At baseline, these youth were 12-14 year-olds free from any psychiatric disorder with, on average, one alcohol use experience, and nearly half at risk for AUD based on family history. Baseline assessments, now complete, included neuropsychological testing and brain imaging with high resolution MRI, FMRI acquisition during working memory and alcohol cue presentation tasks, and diffusion tensor imaging (DTI). In this competing renewal, we will continue to follow these adolescents with quarterly interviews on substance use and general functioning. Each subject who initiates heavy drinking (defined as at least monthly binge drinking episodes), as well as a non-user matched for age, gender, and family history, will be invited back to repeat the protocol 3 times during this 5-year period (independent of whether they remain heavy drinkers or transition out during the duration of the project). As of Year 09, 29% (n=86) have initiated heavy drinking (most typically at age 17), and 61% (n=181) have remained non-drinkers/users (28 fall into neither group).
Aims : The goal of this project now is to ascertain if indices of brain functioning (i.e., neuropsychological testing;hippocampal, prefrontal cortex, and cerebellar volumes;white matter microstructural integrity in frontoparietal and fronto-cerebellar tracks, and FMRI response to working memory in frontal and parietal regions and to alcohol cues in reward networks changes after the onset of heavy drinking to a different degree than observed in typically developing adolescents of the same age who do not use substances. We hypothesize that initiation of heavy drinking during adolescence will be associated with alternations in brain structure and function, and that gender will moderate this relationship. Other substance use (marijuana and nicotine) and other risk factors for AUD (externalizing behaviors, level of response to alcohol, and alcohol expectancies) will be evaluated as potential contributors to change in brain functioning. Based on our previous studies, we further hypothesize that baseline brain response patterns will significantly predict substance use involvement and outcomes. Pilot analyses will begin to look at normalization of these neural abnormalities, as some young adults transition out of heavy drinking.

Public Health Relevance

Alcohol is the most commonly used intoxicant for youth. Brain function and structure abnormalities have been seen in young heavy drinkers. Longitudinal studies following youth well characterized prior to drinking onset are essential to determine the contribution of heavy alcohol use on abnormalities observed in heavy drinkers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA013419-12
Application #
8735004
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Witt, Ellen
Project Start
2002-02-01
Project End
2018-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
12
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Squeglia, Lindsay M; Ball, Tali M; Jacobus, Joanna et al. (2016) Neural Predictors of Initiating Alcohol Use During Adolescence. Am J Psychiatry :appiajp201615121587
Jacobus, Joanna; Castro, Norma; Squeglia, Lindsay M et al. (2016) Adolescent cortical thickness pre- and post marijuana and alcohol initiation. Neurotoxicol Teratol 57:20-29
Brumback, T Y; Worley, Matthew; Nguyen-Louie, Tam T et al. (2016) Neural predictors of alcohol use and psychopathology symptoms in adolescents. Dev Psychopathol 28:1209-1216
Brumback, T; Castro, N; Jacobus, J et al. (2016) Effects of Marijuana Use on Brain Structure and Function: Neuroimaging Findings from a Neurodevelopmental Perspective. Int Rev Neurobiol 129:33-65
Nguyen-Louie, Tam T; Tracas, Ashley; Squeglia, Lindsay M et al. (2016) Learning and Memory in Adolescent Moderate, Binge, and Extreme-Binge Drinkers. Alcohol Clin Exp Res 40:1895-904
Squeglia, Lindsay M; Sorg, Scott F; Jacobus, Joanna et al. (2015) Structural connectivity of neural reward networks in youth at risk for substance use disorders. Psychopharmacology (Berl) 232:2217-26
Brumback, Ty; Squeglia, Lindsay M; Jacobus, Joanna et al. (2015) Adolescent heavy drinkers' amplified brain responses to alcohol cues decrease over one month of abstinence. Addict Behav 46:45-52
Squeglia, Lindsay M; Tapert, Susan F; Sullivan, Edith V et al. (2015) Brain development in heavy-drinking adolescents. Am J Psychiatry 172:531-42
Nguyen-Louie, Tam T; Castro, Norma; Matt, Georg E et al. (2015) Effects of Emerging Alcohol and Marijuana Use Behaviors on Adolescents' Neuropsychological Functioning Over Four Years. J Stud Alcohol Drugs 76:738-48
Jacobus, Joanna; Squeglia, Lindsay M; Meruelo, Alejandro D et al. (2015) Cortical thickness in adolescent marijuana and alcohol users: A three-year prospective study from adolescence to young adulthood. Dev Cogn Neurosci 16:101-9

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