Chronic binge drinking represents a major health and safety problem in our country. The adverse effects of this excessive use are widespread in terms of loss of life, productivity, accidents and harm. Persons who are chronic, heavy alcohol drinkers (i.e., consume 5 or more drinks on a weekly or more frequent basis) incur greater consequences if they maintain hazardous drinking levels and are also at increased risk for progression to Alcohol Dependence compared with non heavy drinkers. The goal of the proposed renewal application is to build on findings from the first phase to further elucidate the factors associated with escalation and maintenance of excessive ethanol drinking. In the first award phase, we supported the hypothesis that heavy binge social drinkers are more sensitive to the positive and rewarding effects of alcohol during rising blood alcohol concentrations, and are also less sensitive to sedating effects and cortisol response to alcohol compared with light drinkers. Sensitivity to the stimulant-like effects and tolerance to sedative-like effects of alcohol were associated with greater frequency of binge drinking over the first two years after the baseline laboratory sessions. In this renewal application, we propose to recruit and test a second cohort of 100 HDs, to increase sample size to N=290 (204 heavy and 86 light drinkers).
In Aim 1, we will examine the role of acute alcohol responses (stimulation, sedation, wanting, cortisol, performance measures, etc.) to future drinking behaviors over time.
In Aim 2, we propose to re-examine alcohol response five years after the initial determination from the last award period in the first cohort of subjects. The data will discern whether alcohol responses vary over time, and in whom, and if alcohol drinking in the intervening period moderates the relationship between baseline and re-examination response. The study paradigm provides a unique translational focus on intensive laboratory data combined with long-term prospective follow-up. We will determine the relative contributions of sensitivity to stimulant-like alcohol effects, tolerance to sedative-like effects, and objective responses (cortisol, performance, heart rate, etc.) to future drinking patterns over time. Such information may have important impact on the early identification of at-risk drinkers and the factors underlying hazardous drinking practices to improve prevention, education, and early intervention efforts.

Public Health Relevance

Chronic heavy or binge alcohol drinking remains a serious problem in this country and the consequences of this excessive use are widespread. This study will conduct long-term examination of response to alcohol in the laboratory and drinking patterns over time in a well-established cohort of young adult binge and light social drinkers. Equally important, the potential protective factors underlying low risk drinking will also be examined.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Project (R01)
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Special Emphasis Panel (ZAA1-JJ (10))
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Matochik, John A
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University of Chicago
Schools of Medicine
United States
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Rueger, Sandra Y; Hu, Hongxing; McNamara, Patrick et al. (2015) Differences in subjective response to alcohol in heavy- and light-drinking Chinese men versus Caucasian American men. Addiction 110:91-9
King, Andrea C; McNamara, Patrick J; Hasin, Deborah S et al. (2014) Alcohol challenge responses predict future alcohol use disorder symptoms: a 6-year prospective study. Biol Psychiatry 75:798-806
Roche, Daniel J O; Palmeri, Michael D; King, Andrea C (2014) Acute alcohol response phenotype in heavy social drinkers is robust and reproducible. Alcohol Clin Exp Res 38:844-52
Rueger, Sandra Y; King, Andrea C (2013) Validation of the brief Biphasic Alcohol Effects Scale (B-BAES). Alcohol Clin Exp Res 37:470-6
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King, Andrea C; de Wit, Harriet; McNamara, Patrick J et al. (2011) Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking. Arch Gen Psychiatry 68:389-99
Sripada, Chandra Sekhar; Angstadt, Mike; McNamara, Patrick et al. (2011) Effects of alcohol on brain responses to social signals of threat in humans. Neuroimage 55:371-80
King, Andrea; McNamara, Patrick; Angstadt, Michael et al. (2010) Neural substrates of alcohol-induced smoking urge in heavy drinking nondaily smokers. Neuropsychopharmacology 35:692-701

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