Alcohol binge drinking is associated with dangerous levels of intoxication that are costly to both the individual and society. NIAAA (2004) and others have defined a "binge" as a drinking episode that produces a blood alcohol concentration of e .08 percent, which typically corresponds to five drinks for men and four drinks for women consumed within 2 hours. Most of what is known about binge drinking is based on studies of college students, however, most binge drinkers are older adults. One mechanism that may play an important role in alcohol binging is a "loss of control" (or increased impulsivity) occurring after the initial consumption of alcohol. Recent evidence suggests that individuals with reduced serotonin function may experience disproportionate increases in impulsivity after consuming alcohol. The proposed study of binge and non-binge drinkers will determine how impulsivity is affected by alcohol and/or reductions in serotonin synthesis, and then to determine how these observed effects are related to the capacity to modify drinking patterns. Adult Binge (n = 224) and Non-Binge (n = 56) drinkers between the ages of 26 and 54 will be recruited from the community and participate in four study phases. In Phase I, participants complete a battery of different impulsivity measures during a simulated alcohol binge procedure, after a procedure altering L-tryptophan availability (affecting serotonin synthesis). Conditions include: (1) alcohol consumed after L-tryptophan depletion;(2) placebo consumed after L- tryptophan depletion;(3) alcohol consumed after L-tryptophan balanced control;and (4) placebo consumed after L-tryptophan balanced control. In Phase II, drinking patterns among the two groups are characterized using continuous transdermal alcohol monitoring (and self-report) across a 4-week period. In Phase 3, Binge drinkers complete a 12-week contingency management procedure designed to reduce alcohol consumption and produce a range of drinking outcomes. Lastly, in Phase 4, participants experience a brief motivational interview and patterns of drinking are re-evaluated monthly for 3 months. This study allows us to address three primary aims: to characterize behavioral impulsivity among adult Binge and Non-Binge drinkers, as well as their responses during a simulated alcohol binge and/or L-tryptophan depletion challenges (Aim 1);to use a 12-week contingency management procedure to determine to what extent individual differences in the capacity to reduce drinking among alcohol bingers is related to the behavioral impulsivity responses observed during the alcohol and/or L-tryptophan depletion challenge procedures (Aim 2);and to determine to what extent reductions in drinking achieved during contingency management can be maintained across a 3-month follow- up period that begins with a brief motivational interview, and to determine whether behavioral responses observed in Specific Aim 1 predict observed outcomes (Aim 3). This study represents a critically important step by relating biological and behavioral markers to outcomes observed in the "real world" and will lay the groundwork necessary for future studies.

Public Health Relevance

Alcohol binge drinking produces dangerous levels of intoxication and acute health consequence that confer immediate risks to both the individual and society. The proposed study will provide fundamental information on how specific behavioral processes relate to individual differences in the ability to reduce alcohol consumption. The results of this study will inform the development of treatments aimed at this unique population of problem drinkers, and inform us about how differences in these markers might be used by clinicians to match treatment plans to specific individuals.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA014988-09
Application #
8242766
Study Section
Special Emphasis Panel (ZRG1-BBBP-R (02))
Program Officer
Grakalic, Ivana
Project Start
2004-06-01
Project End
2015-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
9
Fiscal Year
2012
Total Cost
$545,966
Indirect Cost
$172,428
Name
University of Texas Health Science Center San Antonio
Department
Psychiatry
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Hill-Kapturczak, Nathalie; Roache, John D; Liang, Yuanyuan et al. (2015) Accounting for sex-related differences in the estimation of breath alcohol concentrations using transdermal alcohol monitoring. Psychopharmacology (Berl) 232:115-23
Hill-Kapturczak, Nathalie; Lake, Sarah L; Roache, John D et al. (2014) Do variable rates of alcohol drinking alter the ability to use transdermal alcohol monitors to estimate peak breath alcohol and total number of drinks? Alcohol Clin Exp Res 38:2517-22
Dougherty, Donald M; Hill-Kapturczak, Nathalie; Liang, Yuanyuan et al. (2014) Use of continuous transdermal alcohol monitoring during a contingency management procedure to reduce excessive alcohol use. Drug Alcohol Depend 142:301-6
Acheson, Ashley; Richard, Dawn M; Mathias, Charles W et al. (2011) Adults with a family history of alcohol related problems are more impulsive on measures of response initiation and response inhibition. Drug Alcohol Depend 117:198-203
Badawy, Abdulla A-B; Dougherty, Donald M; Richard, Dawn M (2010) Specificity of the Acute Tryptophan and Tyrosine Plus Phenylalanine Depletion and Loading Tests Part II: Normalisation of the Tryptophan and the Tyrosine Plus Phenylalanine to Competing Amino Acid Ratios in a New Control Formulation. Int J Tryptophan Res 3:35-47
Badawy, Abdulla A-B; Dougherty, Donald M; Richard, Dawn M (2010) Specificity of the Acute Tryptophan and Tyrosine Plus Phenylalanine Depletion and Loading Tests I. Review of Biochemical Aspects and Poor Specificity of Current Amino Acid Formulations. Int J Tryptophan Res 2010:23-34
Badawy, Abdulla A-B; Doughrty, Donald M; Marsh-Richard, Dawn M et al. (2009) Activation of liver tryptophan pyrrolase mediates the decrease in tryptophan availability to the brain after acute alcohol consumption by normal subjects. Alcohol Alcohol 44:267-71
Dougherty, Donald M; Mathias, Charles W; Marsh-Richard, Dawn M et al. (2009) Distinctions in Behavioral Impulsivity: Implications for Substance Abuse Research. Addict Disord Their Treat 8:61-73
Marsh-Richard, Dawn M; Hatzis, Erin S; Mathias, Charles W et al. (2009) Adaptive Visual Analog Scales (AVAS): a modifiable software program for the creation, administration, and scoring of visual analog scales. Behav Res Methods 41:99-106
Dougherty, Donald M; Marsh-Richard, Dawn M; Hatzis, Erin S et al. (2008) A test of alcohol dose effects on multiple behavioral measures of impulsivity. Drug Alcohol Depend 96:111-20

Showing the most recent 10 out of 12 publications