Adolescence is a developmental period during which individuals engage in risk-taking behavior and are likely to initiate use of alcohol or other drugs. Past research suggests a strong correlation between early age of onset of alcohol use and a heightened vulnerability to addiction later in life. Adolescence is also a time of considerable neuromaturation, particularly in frontal brain regions thought to subserve higher level cognition, such as decision making and inhibition. Heavy alcohol use during these critical periods of brain development may permanently disrupt the course of maturation, resulting in long-term deficits in these functions and thereby increasing the risk of subsequent substance use behavior. The proposed R01 project is designed to prospectively and longitudinally examine the influence of developmental stage on the effects of alcohol on adolescent cognition, brain functioning, and brain structure, using neuroimaging and neuropsychological testing techniques. This project will examine neuropsychological performance during tests of executive functioning, brain functioning during executive and risk taking fMRI tasks, brain structure in prefrontal and limbic regions, and frontostriatal white matter integrity in 250 at-risk, non-using 12-14-year-old youth (based on family history of alcoholism). We hypothesize that youth who drink in adolescence will show abnormalities on these measures compared to developmentally-matched non-drinking youth, and that youth who initiate heavy drinking earlier in puberty will show greater abnormalities than teens that initiate heavy drinking later in development. This prospective study will answer critical questions about how developmental timing of adolescent heavy alcohol use initiation affects the developing brain.

Public Health Relevance

Studies show that the adolescent brain may be particularly vulnerable to alcohol's neurotoxic effects, and that earlier use is associated with greater subsequent risk of addictive behaviors. Despite this, alcohol use is very common among adolescence. Understanding the impact of early alcohol use on the developing adolescent brain will facilitate the creation of interventions aimed at reducing alcohol drinking behaviors that are targeted at specific age and risk groups.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA017664-05
Application #
8515884
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Witt, Ellen
Project Start
2009-09-20
Project End
2014-08-31
Budget Start
2013-09-20
Budget End
2014-08-31
Support Year
5
Fiscal Year
2013
Total Cost
$295,101
Indirect Cost
$84,919
Name
Oregon Health and Science University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Cservenka, Anita; Fair, Damien A; Nagel, Bonnie J (2014) Emotional processing and brain activity in youth at high risk for alcoholism. Alcohol Clin Exp Res 38:1912-23
Alarcón, Gabriela; Cservenka, Anita; Fair, Damien A et al. (2014) Sex differences in the neural substrates of spatial working memory during adolescence are not mediated by endogenous testosterone. Brain Res 1593:40-54
Herting, Megan M; Colby, John B; Sowell, Elizabeth R et al. (2014) White matter connectivity and aerobic fitness in male adolescents. Dev Cogn Neurosci 7:65-75
Nagel, Bonnie J (2014) Brain connectivity and applications to neuropsychology: introduction to the special issue of Neuropsychology Review. Neuropsychol Rev 24:1-2
Cservenka, Anita; Casimo, Kaitlyn; Fair, Damien A et al. (2014) Resting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism. Psychiatry Res 221:210-9
Herting, Megan M; Nagel, Bonnie J (2013) Differences in brain activity during a verbal associative memory encoding task in high- and low-fit adolescents. J Cogn Neurosci 25:595-612
Seghete, Kristen L Mackiewicz; Herting, Megan M; Nagel, Bonnie J (2013) White matter microstructure correlates of inhibition and task-switching in adolescents. Brain Res 1527:15-28
Nagel, Bonnie J; Herting, Megan M; Maxwell, Emily C et al. (2013) Hemispheric lateralization of verbal and spatial working memory during adolescence. Brain Cogn 82:58-68
Mackiewicz Seghete, Kristen L; Cservenka, Anita; Herting, Megan M et al. (2013) Atypical spatial working memory and task-general brain activity in adolescents with a family history of alcoholism. Alcohol Clin Exp Res 37:390-8
Cservenka, Anita; Herting, Megan M; Nagel, Bonnie J (2012) Atypical frontal lobe activity during verbal working memory in youth with a family history of alcoholism. Drug Alcohol Depend 123:98-104

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