During the development of addiction, the pursuit of drugs of abuse, such as alcohol, becomes progressively less goal-directed and progressively more habitual coming under the control of internal and external states and stimuli. Understandably, therefore, recent theory and research on alcoholism has started to focus on the habit learning process and its behavioral and neural bases. It is important, however, to distinguish habitual drug-seeking from other forms of habitual behavior. Under normal conditions, habit learning can be highly adaptive;habits allow us and other animals to relegate the control of routine behavioral responses to a system that uses few cognitive resources freeing up this limited capacity for tasks that need greater monitoring. Unlike goal-directed actions that are quickly acquired and flexibly deployed, habits are usually slowly acquired, stimulus-bound and inflexible. Nevertheless, their deployment can be rapidly suppressed when conditions change. Driving, cycling, even walking would be very dangerous activities if we couldn't quickly and reliably suppress these habits as and when circumstances change to navigate around an obstacle. In contrast, habitual drug seeking is pathological;drug exposure appears both to increase the rate of habit acquisition and the influence of drug associated contexts and cues on their performance. Furthermore, despite the heavy emphasis on habit processes in current research, a distinguishing feature of habitual drug seeking is the addicts'loss of executive and behavioral control over the habit;drug seeking persists even in the face of severe negative consequences. The compulsive pursuit of alcohol can be viewed, therefore, as the product of two interacting processes: (i) an alcohol-induced increment in the acquisition of habitual alcohol seeking and (ii) an alcohol-induced decrement in the addict's ability to exert control over the habit in the face of persistent, sometimes extreme negative feedback. It is important to recognize, however, that these effects of alcohol exposure extend beyond alcohol seeking and appear to have an effect on decision-making and adaptive behavioral control more generally. It is likely, therefore, that alcohol exposure produces extensive changes in the larger neural systems that control the acquisition and performance of goal-directed and habitual actions. Given these considerations, the broad objective of the current project is to assess the effect of alcohol exposure on the behavioral and neural determinants of (i) goal directed learning, (ii) habit learning and (iii) the processes that control the degree to which these learning processes are implemented in performance.

Public Health Relevance

The transition from casual drinking to compulsive alcohol seeking may stem from alcohol's tendency to disrupt the cognitive and behavioral processes that guide action selection and decision making more generally. In instrumental conditioning, the behavioral processes, and the corresponding neural systems, responsible for goal-directed action selection and habitual performance have been relatively well characterized. The broad, long-term objective of the current project is, therefore, to investigate how exposure to alcohol affects the neural systems that control goal-directed and habitual instrumental learning processes.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA018014-06
Application #
8274321
Study Section
Special Emphasis Panel (ZAA1-CC (02))
Program Officer
Grakalic, Ivana
Project Start
2008-09-30
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2014-05-31
Support Year
6
Fiscal Year
2012
Total Cost
$196,896
Indirect Cost
$14,585
Name
University of Sydney
Department
Type
DUNS #
752389338
City
Sydney
State
Country
Australia
Zip Code
2006
Ostlund, Sean B; Wassum, Kate M; Murphy, Niall P et al. (2011) Extracellular dopamine levels in striatal subregions track shifts in motivation and response cost during instrumental conditioning. J Neurosci 31:200-7
Wassum, Kate M; Cely, Ingrid C; Balleine, Bernard W et al. (2011) Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward. J Neurosci 31:1591-9
Wassum, K M; Cely, I C; Maidment, N T et al. (2009) Disruption of endogenous opioid activity during instrumental learning enhances habit acquisition. Neuroscience 163:770-80
Ostlund, Sean B; Balleine, Bernard W (2008) On habits and addiction: An associative analysis of compulsive drug seeking. Drug Discov Today Dis Models 5:235-245