Studies have consistently shown an association between mental health disorders and alcohol use disorders (AUD) during adolescence. In particular, the comorbidity of AUD with Major Depressive Disorder (MDD) is well established and associated with a range of negative outcomes including longer and more severe episodes of illness and greater psychosocial impairment including behavior disturbance. This population may be even more challenging to treat than their adult counterparts because adolescents with MDD/AUD so often have other externalizing disorders besides AUD. Treatment research for this population is quite limited and Healthy People 2020 Objective MHMD HP 2020-14 directly addresses this area: increase the proportion of persons with co-occurring substance abuse and mental disorders who receive treatment for both disorders. The purpose of this application is to conduct a randomized clinical trial comparing Cognitive Behavioral Therapy - Integrated (CBT- I) for adolescents with MDD and AUD to standard care (SC), i.e. an eclectic mix of therapy techniques. A two group randomized design will be used to test the primary hypothesis that the integrated CBT- I protocol designed to treat adolescents aged 12 to 18 years with AUD/ MDD will produce better treatment outcomes compared to standard care with respect to 1) heavy volume alcohol use/ alcohol problems which can contribute to both depression and externalizing behaviors, the most severe of which result in costly residential placements and arrests/incarceration; and 2) depression and suicidal events, the latter potentially requiring expensive Emergency Department visits and inpatient psychiatric hospitalizations. Both the integrated CBT-I and SC condition will be delivered by licensed mental health counselors at a community mental health clinic that uses an Intensive Outpatient Program model to treat adolescents with AUD and mental health disorders who have failed prior outpatient therapy and require more intensive services. Clinicians in the CBT-I condition will receive weekly supervision that focuses on use of the CBT-I protocol. Clinicians in SC will be provided standard clinic supervision that is more eclectic in nature, consistent with typical community care. Outcome data will be collected at one year post treatment. Successful completion of the project aims could change how services are delivered to this high risk group. Its clinical significance lies in ts addressing a critical barrier to the field: how to treat MDD/AUD adolescents.

Public Health Relevance

Adolescents who have both alcohol use disorders and psychiatric disorders typically have major impairment that affects multiple aspects of their functioning. Improved methods for treating these individuals have the potential to decrease the morbidity associated with both conditions. The relevance of this problem is reflected in Healthy People 2020 Objective MHMD HP 2020-14 which reads: 'increase the proportion of persons with co-occurring substance abuse and mental disorders who receive treatment for both disorders.'

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA020705-04
Application #
8828027
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Roach, Deidra
Project Start
2012-04-20
Project End
2017-03-31
Budget Start
2015-04-01
Budget End
2016-03-31
Support Year
4
Fiscal Year
2015
Total Cost
$681,323
Indirect Cost
$180,788
Name
Brown University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Ge, Liangpeng; Cao, Chuan; Chen, Shixuan et al. (2017) Preparation of laminin/nidogen adsorbed urinary bladder decellularized materials via a mussel-inspired polydopamine coating for pelvic reconstruction. Am J Transl Res 9:5289-5298
Kelly, Lourah M; Becker, Sara J; Wolff, Jennifer C et al. (2017) Interactive Effect of Parent and Adolescent Psychiatric Symptoms on Substance Use among Adolescents in Community Treatment. Community Ment Health J 53:383-393
Zhou, Xianyu; Luo, Xusong; Gao, Bowen et al. (2017) A series of rat segmental forelimb ectopic implantation models. Sci Rep 7:1607
Shen, Congcong; Sun, Linlin; Zhu, Ningwen et al. (2017) Kindlin-1 contributes to EGF-induced re-epithelialization in skin wound healing. Int J Mol Med 39:949-959
Zhou, Xianyu; Luo, Xusong; Liu, Fei et al. (2016) A novel animal model for skin flap prelamination with biomaterials. Sci Rep 6:34144
Liu, Jiaqi; Gu, Jianying; Feng, Zihao et al. (2016) Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells. J Transl Med 14:7
Xue, Ke; Zhang, Xiaodie; Qi, Lin et al. (2016) Isolation, identification, and comparison of cartilage stem progenitor/cells from auricular cartilage and perichondrium. Am J Transl Res 8:732-41
Gomez, Judelysse; Becker, Sara; O'Brien, Kimberly et al. (2015) Interactive Effect of Child Maltreatment and Substance Use on Depressed Mood Among Adolescents Presenting to Community-Based Substance Use Treatment. Community Ment Health J 51:833-40
Yang, Zhen; Liu, Jiaqi; Zhu, Ningwen et al. (2015) Comparison between hair follicles and split-thickness skin grafts in cutaneous wound repair. Int J Clin Exp Med 8:15822-7