Recently our research group published a paper in JAMA which showed that after Roux-en-Y gastric bypass surgery (RYGB), patients are at significantly increased risk for developing an alcohol use disorder. Several lines of research are consistent with this finding: 1) anecdotal information from RYGB patients suggests that they become intoxicated much more quickly, 2) there are numerous reports of automobile accidents that have resulted from RYGB patients driving while intoxicated after drinking a small amount of alcohol, and 3) the pharmacokinetics of alcohol change considerably after RYGB. The pharmacokinetic changes are of considerable interest to us as they likely lead to significant impairments and changes in reinforcement. These changes may serve as a potential causal mechanism for the subsequent development of an alcohol use disorder. In the current study we propose to investigate RYGB patients with a prospective, longitudinal design. We will examine cognitive and driving impairment after surgery as well as study the changes in reinforcement that may occur in RYGB patients. Finally, we aim to better characterize the changes that occur in the pharmacokinetics of alcohol following bariatric surgery and examine key variables which may play a role in the development in alcohol use disorders.

Public Health Relevance

The proposed project will help to understand the changes in impairment experienced by bariatric surgery patients who consume alcohol. Studying this will help future bariatric surgery patients better understand how the effects of alcohol will change from pre- to post-surgery and the proposed study will help to better understand possible mechanisms for an increased risk for alcohol use disorder in this group.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
1R01AA022336-01A1
Application #
8648825
Study Section
Risk, Prevention and Intervention for Addictions Study Section (RPIA)
Program Officer
Brooks, Pj
Project Start
2014-09-10
Project End
2019-06-30
Budget Start
2014-09-10
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
$412,794
Indirect Cost
$121,656
Name
Neuropsychiatric Research Institute
Department
Type
DUNS #
068157924
City
Fargo
State
ND
Country
United States
Zip Code
58103