The aim of this study is to identify risk factors for Alzheimer's disease (AD), dementia, as well as cognitive impairment and cognitive decline, by comparing two populations from very different environments, elderly African Americans from Indianapolis, and the elderly Yoruba from Ibadan, Nigeria. During the current grant periods, our cohorts were enriched by enrolling new participants (Indianapolis: 1,893;Ibadan: 1,942) to add to the survivors of the original cohort. In addition, blood samples were collected (Indianapolis: 1,545;Ibadan: 1,390) for biochemical and genetic analyses. We propose to conduct two incidence studies in the enriched cohorts, two years apart, to address the following Specific Aims:
Specific Aim 1 : To examine the interaction of APOE4 and lipid levels as risk factors for incident AD and mild cognitive impairment (MCI) in the African Americans and the Yoruba.
Specific Aim 2 : To examine the relationship between the metabolic syndrome and incident dementia and cognitive impairment no dementia (CIND) in the African Americans and the Yoruba.
Specific Aim 3 : To examine the relationship between homocysteine levels, levels of folic acid, vitamin B12, and incident dementia and CIND at both sites.
Specific Aim 4 : To examine the interaction between indices of social involvement and their change over time with the risk of cognitive decline in the African Americans and the Yoruba.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG009956-19
Application #
7905818
Study Section
Special Emphasis Panel (ZRG1-HOP-Q (02))
Program Officer
Anderson, Dallas
Project Start
1996-03-06
Project End
2012-08-31
Budget Start
2010-09-01
Budget End
2012-08-31
Support Year
19
Fiscal Year
2010
Total Cost
$933,797
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Psychiatry
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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Gao, Sujuan; Ogunniyi, Adesola; Hall, Kathleen S et al. (2016) Dementia incidence declined in African-Americans but not in Yoruba. Alzheimers Dement 12:244-51
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Kim, Sungeun; Nho, Kwangsik; Ramanan, Vijay K et al. (2016) Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians. J Alzheimers Dis 49:991-1003
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Jin, Sheng Chih; Carrasquillo, Minerva M; Benitez, Bruno A et al. (2015) TREM2 is associated with increased risk for Alzheimer's disease in African Americans. Mol Neurodegener 10:19
Clark, Daniel O; Gao, Sujuan; Lane, Kathleen A et al. (2014) Obesity and 10-year mortality in very old African Americans and Yoruba-Nigerians: exploring the obesity paradox. J Gerontol A Biol Sci Med Sci 69:1162-9
Gao, Sujuan; Unverzagt, Frederick W; Hall, Kathleen S et al. (2014) Mild cognitive impairment, incidence, progression, and reversion: findings from a community-based cohort of elderly African Americans. Am J Geriatr Psychiatry 22:670-81
Hendrie, Hugh C; Murrell, Jill; Baiyewu, Olusegun et al. (2014) APOE ?4 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba. Int Psychogeriatr 26:977-85

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