The objectives are to determine whether findings of cross-sectional age differences correspond to longitudinal changes in memory and cognition in older adults and to evaluate hypotheses regarding cognitive changes. Considerable effort has been devoted to identifying the mechanisms of change, yet it is not completely clear how memory and cognition changes in individuals as they age. The significance of the present research program is that it charts longitudinal memory change, it assesses individual differences in change, it uses multiple measures of all cognitive constructs and growth models to analyze the data, and it includes evaluation of mortality, practice, and attrition on change. The study uses a multi-sample sequential design with adults ranging in age from 30-97 and follows them at 3 year intervals. Longitudinal changes are compared with change estimates from cross-sectional samples to evaluate the effects of age and cohort. Cohort-sequential modeling makes it possible to evaluate the external validity of cross-sectional designs in estimating memory change. The role of individual differences in memory performance is investigated through analyses of changes in memory predictors including psychometric abilities related to fluid and crystallized abilities, working memory, speed, and other abilities, as well as demographic characteristics including gender, education, health, and affective status. In addition, 25 percent of LBLS subjects will be randomly selected to complete the cognitive measures of the Health and Retirement Study (MRS), a population sample of American adults over age 50. The hypotheses tested are that longitudinal findings assess age changes in memory and cognition more accurately than cross sectional ones;that cohort effects account for many of the age effects observed in memory and cognition, but not at the end of the life span due to selection in very old age;that there is structural invariance longitudinally in the factors measured, but that different tasks are differentially predicted by factors because of task demands;and that younger cohorts, as exemplified by the Baby Boomers, may experience fewer negative effects of cognitive aging than their predecessors. Results of this research will not only provide answers to important methodological questions regarding change in memory, but they also address a number of issues related to individual differences in intraindividual change in cognition, and suggest possible mechanisms of change in healthy older adults. People are concerned about their mental abilities, an important aspect of health and well-being, as they get older. This research focuses on age changes in ability to think, remember, reason, use language, and make plans: what changes are normal, whether there is one particular age where changes occur more rapidly, what changes are due to health problems, and whether the baby boomers will experience fewer changes in their mental abilities.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG010569-15
Application #
8131631
Study Section
Cognition and Perception Study Section (CP)
Program Officer
King, Jonathan W
Project Start
1997-10-01
Project End
2013-08-31
Budget Start
2011-09-01
Budget End
2013-08-31
Support Year
15
Fiscal Year
2011
Total Cost
$469,479
Indirect Cost
Name
University of Southern California
Department
Type
Other Domestic Higher Education
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Brown, Cassandra L; Robitaille, Annie; Zelinski, Elizabeth M et al. (2016) Cognitive activity mediates the association between social activity and cognitive performance: A longitudinal study. Psychol Aging 31:831-846
Skinner, Jeannine; Carvalho, Janessa O; Potter, Guy G et al. (2012) The Alzheimer's Disease Assessment Scale-Cognitive-Plus (ADAS-Cog-Plus): an expansion of the ADAS-Cog to improve responsiveness in MCI. Brain Imaging Behav 6:489-501
Hindin, Shoshana B; Zelinski, Elizabeth M (2012) Extended practice and aerobic exercise interventions benefit untrained cognitive outcomes in older adults: a meta-analysis. J Am Geriatr Soc 60:136-41
Mitchell, Meghan B; Cimino, Cynthia R; Benitez, Andreana et al. (2012) Cognitively Stimulating Activities: Effects on Cognition across Four Studies with up to 21 Years of Longitudinal Data. J Aging Res 2012:461592
Brown, Cassandra L; Gibbons, Laura E; Kennison, Robert F et al. (2012) Social activity and cognitive functioning over time: a coordinated analysis of four longitudinal studies. J Aging Res 2012:287438
Lindwall, Magnus; Cimino, Cynthia R; Gibbons, Laura E et al. (2012) Dynamic associations of change in physical activity and change in cognitive function: coordinated analyses of four longitudinal studies. J Aging Res 2012:493598
Lewis, Kayan L; Zelinski, Elizabeth M (2010) List and text recall differ in their predictors: replication over samples and time. J Gerontol B Psychol Sci Soc Sci 65:449-58
Zelinski, Elizabeth M (2009) Far transfer in cognitive training of older adults. Restor Neurol Neurosci 27:455-71
Smith, Glenn E; Housen, Patricia; Yaffe, Kristine et al. (2009) A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study. J Am Geriatr Soc 57:594-603
Zelinski, Elizabeth M; Reyes, Ricardo (2009) Cognitive benefits of computer games for older adults. Gerontechnology 8:220-235

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