Abstract

This proposal consists of three studies concerned with the clinicopathological correlates and neuropsychological features of the Lewy body variant (LBV) of Alzheimer's disease (AD). In a retrospective study, neuropathological findings will be correlated with neuropsychological measures obtained during life. Measures of memory, attention, language, executive functions, and constructional abilities will be correlated with the number of Lewy bodies, synapses, plaques, tangles and neurons noted in various cortical and subcortical brain regions. In the first of two prospective studies, patients with clinically-defined probable AD or probable LBV will be compared on many of the neuropsychological measures used in the retrospective study. These comparisons will utilize quantitative and qualitative indices which have been shown to discriminate patients with AD from patients with progressive basal ganglia dementias. It is anticipated that patients with LBV will evidence many of the cognitive deficits associated with basal ganglia dementias. The second prospective study will involve the evaluation of the probable AD and probable LBV patients on three tests of implicit memory (pursuit rotor learning, weight biasing, prism adaptation) that involve the initiation and modification of central motor programs. Based upon previous findings, it is anticipated that the probable LBV patients, but not the probable AD patients, will be impaired on these tasks.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG012963-05
Application #
2732572
Study Section
Mental Disorders of Aging Review Committee (MDA)
Project Start
1994-09-30
Project End
1999-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Neurosciences
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Mitolo, Micaela; Hamilton, Joanne M; Landy, Kelly M et al. (2016) Visual Perceptual Organization Ability in Autopsy-Verified Dementia with Lewy Bodies and Alzheimer's Disease. J Int Neuropsychol Soc 22:609-19
Landy, Kelly M; Salmon, David P; Galasko, Douglas et al. (2015) Motion discrimination in dementia with Lewy bodies and Alzheimer disease. Neurology 85:1376-82
Landy, Kelly M; Salmon, David P; Filoteo, J Vincent et al. (2015) Visual search in Dementia with Lewy Bodies and Alzheimer's disease. Cortex 73:228-39
Salmon, David P; Heindel, William C; Hamilton, Joanne M et al. (2015) Recognition memory span in autopsy-confirmed Dementia with Lewy Bodies and Alzheimer's Disease. Neuropsychologia 75:548-55
Mitolo, Micaela; Salmon, David P; Gardini, Simona et al. (2014) The new Qualitative Scoring MMSE Pentagon Test (QSPT) as a valid screening tool between autopsy-confirmed dementia with Lewy bodies and Alzheimer's disease. J Alzheimers Dis 39:823-32
Hamilton, Joanne M; Salmon, David P; Raman, Rema et al. (2014) Accounting for functional loss in Alzheimer's disease and dementia with Lewy bodies: beyond cognition. Alzheimers Dement 10:171-8
Peavy, Guerry M; Salmon, David P; Edland, Steven D et al. (2013) Neuropsychiatric features of frontal lobeýýdysfunction in autopsy-confirmed patients with lewy bodies and ""pure"" Alzheimer disease. Am J Geriatr Psychiatry 21:509-19
Filoteo, J Vincent; Salmon, David P; Schiehser, Dawn M et al. (2009) Verbal learning and memory in patients with dementia with Lewy bodies or Parkinson's disease with dementia. J Clin Exp Neuropsychol 31:823-34
Salmon, David P; Bondi, Mark W (2009) Neuropsychological assessment of dementia. Annu Rev Psychol 60:257-82
Fine, Eric M; Delis, Dean C; Wetter, Spencer R et al. (2008) Identifying the ""source"" of recognition memory deficits in patients with Huntington's disease or Alzheimer's disease: evidence from the CVLT-II. J Clin Exp Neuropsychol 30:463-70

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