There are three overarching goals for the proposed renewal: a) further document in detail the biology, epidemiology and behavior of aging among the Tsimane, a forager-horticultural society living in a pre-modern context, and how it changes with acculturation, utilizing further modern methodologies and individual longitudinal data;b) test the hypothesis that aging among the Tsimane is accelerated relative to people in developed nations due to the heavy burden of infectious disease and low energy balance;and c) evaluate a specific theory of human life history and aging developed by the PIs during the course of their research program. To accomplish these goals, there are three specific aims of this competitive renewal.
Aim 1 is to obtain longitudinal sampling of physical and cognitive function, energy production, morbidity, co- morbidity, mortality, and social roles after age 40.
Aim 2 is to determine rates of immunosenescence for both the acquired and innate arms of the immune system.
Aim 3 is to determine rates of vascular, heart and kidney disease, and their associated etiological processes. The continuation of this project will allow us to build a longitudinal profile of a large sample of persons who span the adult age range and to model interactions between infection, nutrition, organ functioning and damage, and physical and cognitive functioning in a population that reached maturity in a pre-modern, highly infectious environment. For each of the four specific aims, we will both compare our results to those obtained in the U.S. and other countries, and model individual variation within the Tsimane population. We will also assess the effects of the within-population variance in acculturation at both the community and individual levels on those outcome variables. In so doing, we will model the effects of changing economic activities, housing conditions, use of medical facilities, Spanish competency, and literacy, and link them to data on health, physical and cognitive status, and mortality. The developing gradients of infection and life expectancy or mortality will provide further data to explore evolutionary hypotheses and to explore the details of the relationships between infection, inflammation and the pathophysiology of aging.

Public Health Relevance

This renewal will provide detailed information on the impacts of infectious disease on health, functional status and mortality in a pre-modern population of forager-horticulturalists of South America experiencing similar demographic conditions as those in mid-19th century Europe. Investigation of arterial, heart and kidney disease in a large sample of older adults can reveal unique insights about the relative contributions of diet, energy expenditure and inflammation due to disease on the rate of physiological aging. In all societies including the contemporary American experience. The results, combined with measures of aging and disease in other populations such as the U.S., Mexico and Indonesia, may help to explain the historical increases in life expectancy over the past several centuries.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG024119-07
Application #
8138342
Study Section
Social Sciences and Population Studies Study Section (SSPS)
Program Officer
Haaga, John G
Project Start
2004-09-15
Project End
2015-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
7
Fiscal Year
2011
Total Cost
$288,574
Indirect Cost
Name
University of California Santa Barbara
Department
Social Sciences
Type
Schools of Arts and Sciences
DUNS #
094878394
City
Santa Barbara
State
CA
Country
United States
Zip Code
93106
Blackwell, Aaron D; Urlacher, Samuel S; Beheim, Bret et al. (2017) Growth references for Tsimane forager-horticulturalists of the Bolivian Amazon. Am J Phys Anthropol 162:441-461
Stieglitz, Jonathan; Trumble, Benjamin C; Kaplan, Hillard et al. (2017) Horticultural activity predicts later localized limb status in a contemporary pre-industrial population. Am J Phys Anthropol 163:425-436
Gurven, Michael; Fuerstenberg, Eric; Trumble, Benjamin et al. (2017) Cognitive performance across the life course of Bolivian forager-farmers with limited schooling. Dev Psychol 53:160-176
Kaplan, Hillard; Trumble, Benjamin C; Stieglitz, Jonathan et al. (2017) Diet, atherosclerosis, and helmintic infection in Tsimane - Authors' reply. Lancet 390:2035
Jaeggi, Adrian V; Kramer, Karen L; Hames, Raymond et al. (2017) Human grooming in comparative perspective: People in six small-scale societies groom less but socialize just as much as expected for a typical primate. Am J Phys Anthropol 162:810-816
Kaplan, Hillard; Thompson, Randall C; Trumble, Benjamin C et al. (2017) Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study. Lancet 389:1730-1739
Trumble, Benjamin C; Stieglitz, Jonathan; Blackwell, Aaron D et al. (2017) Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden. FASEB J 31:1508-1515
Gurven, Michael; Stieglitz, Jonathan; Trumble, Benjamin et al. (2017) The Tsimane Health and Life History Project: Integrating anthropology and biomedicine. Evol Anthropol 26:54-73
Sobolewski, Marissa; Weiss, Bernard; Martin, Melanie et al. (2017) Toxicoanthropology: Phthalate exposure in relation to market access in a remote forager-horticulturalist population. Int J Hyg Environ Health 220:799-809
Gurven, Michael D; Trumble, Benjamin C; Stieglitz, Jonathan et al. (2016) Cardiovascular disease and type 2 diabetes in evolutionary perspective: a critical role for helminths? Evol Med Public Health :

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