The goal of this application is to test the general hypotheses that: (1) early and frequent exposure to pathogens accelerates immune system development and 'primes'the immune system to higher levels of baseline immune activity and 2) this chronic immune system activation throughout life results in more rapid immunosenescence and a decline in the ability to defend against novel pathogens.. The Tsimane are Bolivian forager-horticulturalists that live with no electricity, running water, or waste disposal, and have extremely limited access to modern medicine. To accomplish our goal, there are five specific aims of this competitive revision to the existing R01 "The Human Life Course and the Biodemography of Aging".
Aim 1 is to measure the levels of cytokines, inflammatory biomarkers, and immunoglobulins in Tsimane sera.
Aim 2 is to test cytokine responses during in vitro stimulation of fresh whole-blood with bacterial, viral, and helminthic antigens.
Aim 3 is to quantify in vivo lymphocyte and T-cell populations with flow cytometry to characterize cellular components of immunity by age and sex.
Aim 4 is to test a series of predictions derived from the above two hypotheses.
Aim 5 is investigate the relationships between disease states, functional status, mortality and immune system function. The addition of this project will allow us to build a cross-sectional and longitudinal profile of a large sample of adults to model interactions between infection, immune system development and immunosenescence in a population that reached maturity in a pre-modern, highly infectious environment. We combine four methods to investigate immune responsiveness to infection: 1) physician exams combined with laboratory analysis to diagnosis infections by type;2) measurement of serum cytokines, inflammatory markers and immunoglobulins;3) In vitro whole blood challenges with common and novel helminthic, viral and bacterial antigens;4) flow cytometry to identify number and proportions of memory- and senescent- T and B cell phenotypes.). As the Tsimane are undergoing rapid change, we will also be able to assess within-population variance by examining the effects of acculturation on immunity at the community and individual level. We will also compare our results to those obtained in the U.S. and other countries, to assess the impacts of the infectious burden of disease on immunity over the life course.
of research to public health This renewal will provide detailed information on the impacts of infectious disease on health, functional status and mortality in a pre-modern population of forager-horticulturalists of South America experiencing similar demographic conditions as those in mid-19th century Europe. Investigation of arterial, heart and kidney disease in a large sample of older adults can reveal unique insights about the relative contributions of diet, energy expenditure and inflammation due to disease on the rate of physiological aging. in all societies including the contemporary American experience. The results, combined with measures of aging and disease in other populations such as the U.S., Mexico and Indonesia, may help to explain the historical increases in life expectancy over the past several centuries.
|Miner, Emily J; Gurven, Michael; Kaplan, Hillard et al. (2014) Sex difference in travel is concentrated in adolescence and tracks reproductive interests. Proc Biol Sci 281:20141476|
|Veile, Amanda; Martin, Melanie; McAllister, Lisa et al. (2014) Modernization is associated with intensive breastfeeding patterns in the Bolivian Amazon. Soc Sci Med 100:148-58|
|Gurven, Michael; VON Rueden, Christopher; Stieglitz, Jonathan et al. (2014) The evolutionary fitness of personality traits in a small-scale subsistence society. Evol Hum Behav 35:|
|von Rueden, Christopher; Gurven, Michael; Kaplan, Hillard et al. (2014) Leadership in an egalitarian society. Hum Nat 25:538-66|
|Trumble, Benjamin C; Smith, Eric A; O'Connor, Kathleen A et al. (2014) Successful hunting increases testosterone and cortisol in a subsistence population. Proc Biol Sci 281:20132876|
|Hodges-Simeon, Carolyn R; Gurven, Michael; Cardenas, Rodrigo A et al. (2013) Voice change as a new measure of male pubertal timing: a study among Bolivian adolescents. Ann Hum Biol 40:209-19|
|Gurven, Michael; von Rueden, Christopher; Massenkoff, Maxim et al. (2013) How universal is the Big Five? Testing the five-factor model of personality variation among forager-farmers in the Bolivian Amazon. J Pers Soc Psychol 104:354-70|
|Trumble, Benjamin C; Cummings, Daniel K; O'Connor, Kathleen A et al. (2013) Age-independent increases in male salivary testosterone during horticultural activity among Tsimane forager-farmers. Evol Hum Behav 34:|
|Winking, Jeffrey; Stieglitz, Jonathan; Kurten, Jenna et al. (2013) Polygyny among the Tsimane of Bolivia: an improved method for testing the polygyny-fertility hypothesis. Proc Biol Sci 280:20123078|
|Gurven, Michael; Jaeggi, Adrian V; Kaplan, Hillard et al. (2013) Physical activity and modernization among Bolivian Amerindians. PLoS One 8:e55679|
Showing the most recent 10 out of 30 publications