This is an application to continue research originally started in 2001, and expanded into a longitudinal study, known as the Virginia Cognitive Aging Project (VCAP), in 2005. Over 2,300 adults 18 - 95 years old have now completed at least two longitudinal occasions, with an average of 2.7 occasions and an average time in study of 5.1 years. The research proposed in the next funding period will extend the investigation of short-term longitudinal change in a broad variety of cognitive measures, with particular emphasis on adults under the age of 80. Although previous studies have found little or no cognitive change in longitudinal comparisons involving young and middle-aged adults, this research employs three methodological innovations, variable retest intervals, measurement bursts at each occasion, and continuous recruitment of new participants, that help distinguish age effects from experience (retest) effects, and that increase sensitivity to detect change by taking into account normal short-term variability in performance. Among the primary questions to be investigated are when does normal age-related cognitive change begin, the degree to which changes in different cognitive variables are independent of one another at different periods in adulthood, the role of prior test experience on the direction and magnitude of cognitive change at different ages, the degree to which factors such as one's cognitive or physical lifestyle moderate the amount of age-related change in different cognitive abilities at various periods in adulthood, and how early can normal and pathological trajectories of cognitive aging be distinguished.
Specific aims during the next grant period are to: (1) Expand the characterization of normal cognitive aging across the range from about 18 to 80 years old; (2) Extend the investigation of the role of experience effects on cognitive change; (3) Investigate the structure and nature of cognitive change across different levels of analysis and across a wide range of ages; and (4) Increase sensitivity of VCAP tests to detect early stages of cognitive pathology among VCAP participants.

Public Health Relevance

Cognitive health is an important component of quality of life, particularly at older ages when impairments are more common and may compromise the ability to live independently. Understanding when and why cognitive functioning declines, and distinguishing normal from pathological cognitive aging as early as possible, are therefore increasingly important public health issues as the average age of the population is increasing.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG024270-12
Application #
9197954
Study Section
Cognition and Perception Study Section (CP)
Program Officer
King, Jonathan W
Project Start
2005-06-15
Project End
2020-12-31
Budget Start
2017-03-01
Budget End
2017-12-31
Support Year
12
Fiscal Year
2017
Total Cost
$544,167
Indirect Cost
$199,757
Name
University of Virginia
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Meissel, Emily E E; Salthouse, Timothy A (2016) Relations of Naturally Occurring Variations in State Anxiety and Cognitive Functioning. Pers Individ Dif 98:85-90
Crawford, L Elizabeth; Landy, David; Salthouse, Timothy A (2016) Spatial working memory capacity predicts bias in estimates of location. J Exp Psychol Learn Mem Cogn 42:1434-47
Salthouse, Timothy A (2016) Little relation of adult age with cognition after controlling general influences. Dev Psychol 52:1545-1554
Salthouse, Timothy A (2016) Aging Cognition Unconfounded by Prior Test Experience. J Gerontol B Psychol Sci Soc Sci 71:49-58
Lee, Seonjoo; Habeck, Christian; Razlighi, Qolamreza et al. (2016) Selective association between cortical thickness and reference abilities in normal aging. Neuroimage 142:293-300
Salthouse, Timothy A (2016) Continuity of cognitive change across adulthood. Psychon Bull Rev 23:932-9
Salthouse, Timothy A (2011) What cognitive abilities are involved in trail-making performance? Intelligence 39:222-232
Salthouse, Timothy A (2010) The paradox of cognitive change. J Clin Exp Neuropsychol :1-8
Krueger, Lacy E; Salthouse, Timothy A (2010) Differences in Acquisition, Not Retention, Largely Contribute to Sex Differences in Multitrial Word Recall Performance. Pers Individ Dif 49:768-772
Soubelet, Andrea; Salthouse, Timothy (2010) The role of activity engagement in the relations between Openness/Intellect and cognition. Pers Individ Dif 49:896-901

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