At the core of our sense of self and personal history are emotional memories. Although emotional or stressful experiences tend to be memorable, emotional arousal can also impair various aspects of memory. In recent years, research into arousal and memory has focused on the key role of the amygdala in enhancing perception and memory of emotionally arousing stimuli. But enhanced memory for arousing information is only part of the story-there is also abundant evidence that arousal enhances some aspects of memory while impairing other aspects. The novel arousal-biased competition (ABC) theory tested in this application states that arousal enhances high-priority neural representations but suppresses low-priority neural representations of stimuli. This can account for a broad range of arousal-induced selectivity effects in memory, including findings that initially appear contradictory such as retrograde amnesia vs. enhancement for neutral stimuli preceding arousing stimuli. The proposed studies will test the effect of arousal on low- and high-priority representations and examine how the effects of arousal differ for younger and older adults. Priority will be systematically manipulated both by bottom-up perceptual salience and by top-down goal relevance;studies will examine the nature of age differences in the effects of arousal on short-term memory, long-term memory and memory binding. One key question is whether arousal's enhancement of high priority and suppression of low priority information are two outcomes from the same competitive process, or whether they arise from independent mechanisms. Because older adults show a deficit in suppression, their performance will help address this question. Although the focus of the application is emotional memory, we are likely to learn about the basic mechanisms of enhancement vs. suppression in aging. Despite a long history of findings that older adults show inhibitory deficits, there have been only a few studies examining the neural mechanisms of older adults'impaired suppression. Our studies examine whether their suppression deficits are greater when stimuli priority is determined by top-down goals or by bottom-up salience and how suppression deficits affect long-term memory.

Public Health Relevance

Terrible accidents, declarations of love, schoolyard triumphs and humiliations-these emotional events create lifelong memories, but they can also drive less immediate concerns from our mind.
This research aims to explain how emotional arousal stamps some things in memory while simultaneously rubbing other things out. A comprehensive understanding of the interplay between emotional arousal and memory could lead to advances such as new treatments for post-traumatic stress disorder, changes in how the justice system handles eyewitness testimony and improved techniques for surgeons and other people who must rely on memory under stressful conditions.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project (R01)
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Special Emphasis Panel (ZRG1-RPHB-L (02))
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Nielsen, Lisbeth
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University of Southern California
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Los Angeles
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Sutherland, Matthew R; Mather, Mara (2017) Arousal (but not valence) amplifies the impact of salience. Cogn Emot :1-7
Clewett, David; Sakaki, Michiko; Nielsen, Shawn et al. (2017) Noradrenergic mechanisms of arousal's bidirectional effects on episodic memory. Neurobiol Learn Mem 137:1-14
Barber, Sarah J; Castrellon, Jaime J; Opitz, Philipp et al. (2017) Younger and older adults' collaborative recall of shared and unshared emotional pictures. Mem Cognit 45:716-730
Nashiro, Kaoru; Guevara-Aguirre, Jaime; Braskie, Meredith N et al. (2017) Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans. J Neurosci 37:1696-1707
Clewett, David; Sakaki, Michiko; Huang, Ringo et al. (2017) Arousal amplifies biased competition between high and low priority memories more in women than in men: The role of elevated noradrenergic activity. Psychoneuroendocrinology 80:80-91
Nashiro, Kaoru; Sakaki, Michiko; Braskie, Meredith N et al. (2017) Resting-state networks associated with cognitive processing show more age-related decline than those associated with emotional processing. Neurobiol Aging 54:152-162
Sutherland, Matthew R; McQuiggan, Douglas A; Ryan, Jennifer D et al. (2017) Perceptual salience does not influence emotional arousal's impairing effects on top-down attention. Emotion 17:700-706
Mather, Mara; Joo Yoo, Hyun; Clewett, David V et al. (2017) Higher locus coeruleus MRI contrast is associated with lower parasympathetic influence over heart rate variability. Neuroimage 150:329-335
Tang, Yuchun; Sun, Wei; Toga, Arthur W et al. (2017) A probabilistic atlas of human brainstem pathways based on connectome imaging data. Neuroimage 169:227-239
Greening, Steven G; Lee, Tae-Ho; Mather, Mara (2016) Individual Differences in Anticipatory Somatosensory Cortex Activity for Shock is Positively Related with Trait Anxiety and Multisensory Integration. Brain Sci 6:

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