Improved understanding of the pathogenesis of dementia brings renewed hope that scientists might soon discover disease-modifying treatments for this debilitating disorder. Initial evidence suggests that disease-modifying treatments would be the most effective if clinicians employed them early, in the preclinical phase. Disease-modifying treatments for dementia are likely to have potentially serious side effects or complications, and therefore it will be vital to identify patients as early and accurately as possible. The term cognitive impairment-no dementia (CIND) has been used to describe this preclinical state. CIND captures a broad range of pathways to dysfunction and the course of this condition is variable with some subjects remaining stable for long period while other convert to dementia and other revert to apparent normalcy. In this proposal, we seek to examine the role of cardiovascular risk factors on diagnosed cognitive status cross-sectionally and longitudinally. We propose to do this in the primary care environment where wide-scale treatment of these patients will occur. A random sample of 2000 patients aged 65 and older from the Wishard Health System primary care database will be evaluated and diagnosed. Patients with CIND will be followed (and re-diagnosed) annually for 4 years. Thorough procedures for assessment will assure optimum diagnostic accuracy. The extensive Regenstrief Medical Records System will allow retrospective and prospective capture of a wide range of health and medical information and the mapping of this information onto clinical diagnosis over time. In this way, we will be able to improve our understanding of which older adults with cognitive impairment-no dementia (CIND) will progress to dementia and would thus be the most likely to benefit from early initiation of disease-modifying treatments.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG026096-05
Application #
7803664
Study Section
Special Emphasis Panel (ZRG1-HOP-S (04))
Program Officer
Anderson, Dallas
Project Start
2006-09-01
Project End
2013-04-30
Budget Start
2010-05-01
Budget End
2013-04-30
Support Year
5
Fiscal Year
2010
Total Cost
$552,490
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Psychiatry
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Ganguli, Mary; Fu, Bo; Snitz, Beth E et al. (2014) Vascular risk factors and cognitive decline in a population sample. Alzheimer Dis Assoc Disord 28:9-15
Rexroth, Daniel F; Tennstedt, Sharon L; Jones, Richard N et al. (2013) Relationship of demographic and health factors to cognition in older adults in the ACTIVE study. J Aging Health 25:128S-46S
Salsman, John M; Butt, Zeeshan; Pilkonis, Paul A et al. (2013) Emotion assessment using the NIH Toolbox. Neurology 80:S76-86
Gershon, Richard C; Wagster, Molly V; Hendrie, Hugh C et al. (2013) NIH toolbox for assessment of neurological and behavioral function. Neurology 80:S2-6
Victorson, David; Manly, Jennifer; Wallner-Allen, Kathleen et al. (2013) Using the NIH Toolbox in special populations: considerations for assessment of pediatric, geriatric, culturally diverse, non-English-speaking, and disabled individuals. Neurology 80:S13-9
Yang, Lili; Unverzagt, Frederick W; Jin, Yinlong et al. (2012) Normative data for neuropsychological tests in a rural elderly Chinese cohort. Clin Neuropsychol 26:641-53
Unverzagt, Frederick W; Guey, Lin T; Jones, Richard N et al. (2012) ACTIVE cognitive training and rates of incident dementia. J Int Neuropsychol Soc 18:669-77
Ah, Diane Von; Skaar, Todd; Unverzagt, Fredrick et al. (2012) Evaluating the role of serotonin on neuropsychological function after breast cancer using acute tryptophan depletion. Biol Res Nurs 14:5-15
Unverzagt, Frederick W; Ogunniyi, Adesola; Taler, Vanessa et al. (2011) Incidence and risk factors for cognitive impairment no dementia and mild cognitive impairment in African Americans. Alzheimer Dis Assoc Disord 25:4-10
Fillenbaum, Gerda G; Burchett, Bruce M; Unverzagt, Frederick W et al. (2011) Norms for CERAD constructional praxis recall. Clin Neuropsychol 25:1345-58

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