In the first 5 years of the SOF Sleep and Cognition Study, we utilized objectively measured characteristics of sleep, including wrist actigraphy (n=3,161) and overnight in-home polysomnography (n=461) obtained in primarily community-dwelling older women. Among these women, a subset completed an expanded battery of cognitive function tests five years later and were classified as normal, mild cognitive impairment, or dementia. We demonstrated that several characteristics of sleep (including sleep disordered breathing, sleep quality, and circadian rest-activity rhythms) are associated with risk of incident mild cognitive impairment or dementia, and decline in cognitive function. These novel findings have important implications for the possible prevention and treatment of cognitive impairment. We now propose a cost-effective approach of extending the value of the initial collection of data and specimens supported by the SOF Sleep and Cognition Study to systematically address novel hypotheses focused on the mechanisms linking poor sleep and cognition. In addition, we will extend our follow-up of the initial cohort to identify the independent associations between sleep characteristics and cognitive function with other important age-related outcomes. Thus, the aims of our proposed renewal include: 1) To identify candidate -regions, -genes, and -pathways for both sleep characteristics and cognitive outcomes using recently obtained phenotypic and genome-wide genetic data from the SOF cohort;2) To test the hypothesis that poor sleep is associated with both cross-sectional and longitudinal changes in metabolic dysfunction among older women, and that metabolic dysfunction mediates associations between poor sleep and cognitive outcomes;3) To perform spectral analysis of the polysomnography EEG signal to explore associations between novel sleep exposures (including amounts of delta sleep, dissipation rates of slow wave activity, and spindle-frequency activity) with cross-sectional and longitudinal changes in metabolic dysfunction and inflammation, and with onset of cognitive impairment during 5 years of follow-up;and 4) To determine the independent associations of sleep characteristics and cognitive impairment with incident age-related outcomes including functional decline, nursing home placement, and risk of falls. The new information resulting from this renewal application has the potential to inform the development of new treatments to prevent decline in cognitive function in older adults. In addition, we will take advantage of ongoing follow-up for key age-related outcomes in the SOF study to determine whether sleep and cognition are independently related to risk for these conditions. Ultimately, our results may highlight the importance of maintaining healthy sleep characteristics in older adults to prevent the decline in cognitive and physical function associated with aging.

Public Health Relevance

We have previously shown that sleep disorders and/or disturbances are related to the risk of developing problems with cognitive function. Our new aims will explore several possible explanations for these findings, including common genetic factors, markers of metabolic function which can be measured in blood, and new measures generated from brain wave data obtained during overnight sleep studies. We will also link sleep and cognitive function with outcomes including falls, functional decline and nursing home placement.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
2R01AG026720-06A1
Application #
8462717
Study Section
Special Emphasis Panel (ZRG1-PSE-B (03))
Program Officer
Mackiewicz, Miroslaw
Project Start
2005-07-01
Project End
2016-06-30
Budget Start
2012-09-30
Budget End
2013-06-30
Support Year
6
Fiscal Year
2012
Total Cost
$676,412
Indirect Cost
$137,790
Name
California Pacific Medical Center Research Institute
Department
Type
DUNS #
071882724
City
San Francisco
State
CA
Country
United States
Zip Code
94107
Cade, Brian E; Gottlieb, Daniel J; Lauderdale, Diane S et al. (2016) Common variants in DRD2 are associated with sleep duration: the CARe consortium. Hum Mol Genet 25:167-79
Maglione, Jeanne E; Nievergelt, Caroline M; Parimi, Neeta et al. (2015) Associations of PER3 and RORA Circadian Gene Polymorphisms and Depressive Symptoms in Older Adults. Am J Geriatr Psychiatry 23:1075-87
Slinin, Yelena; Peters, Katherine W; Ishani, Areef et al. (2015) Cystatin C and cognitive impairment 10 years later in older women. J Gerontol A Biol Sci Med Sci 70:771-8
Kaup, Allison R; Nettiksimmons, Jasmine; LeBlanc, Erin S et al. (2015) Memory complaints and risk of cognitive impairment after nearly 2 decades among older women. Neurology 85:1852-8
Gottlieb, D J; Hek, K; Chen, T-H et al. (2015) Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. Mol Psychiatry 20:1232-9
Appiah, Duke; Winters, Stephen J; Muldoon, Susan B et al. (2015) Androgens, Bilateral Oophorectomy, and Cardiovascular Disease Mortality in Postmenopausal Women With and Without Diabetes: The Study of Osteoporotic Fractures. Diabetes Care 38:2301-7
Koyama, Alain; Houston, Denise K; Simonsick, Eleanor M et al. (2015) Association between the Mediterranean diet and cognitive decline in a biracial population. J Gerontol A Biol Sci Med Sci 70:354-9
Gardner, Raquel C; Yaffe, Kristine (2014) Traumatic brain injury may increase risk of young onset dementia. Ann Neurol 75:339-41
Maglione, Jeanne E; Ancoli-Israel, Sonia; Peters, Katherine W et al. (2014) Depressive symptoms and circadian activity rhythm disturbances in community-dwelling older women. Am J Geriatr Psychiatry 22:349-61
Zeki Al Hazzouri, Adina; Vittinghoff, Eric; Byers, Amy et al. (2014) Long-term cumulative depressive symptom burden and risk of cognitive decline and dementia among very old women. J Gerontol A Biol Sci Med Sci 69:595-601

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