Experimental and longitudinal studies have found that older individuals with more negative age beliefs demonstrate worse health outcomes. The mechanism that explains this process is not known. The overall aim of the proposed project is to investigate for the first time whether stress biomarkers over time reflect a biological process tha links negative age beliefs (defined as disparaging perceptions that are assimilated from society about older individuals as a category) with worse health of older individuals. The importance of examining stress biomarkers as the potential mechanism is enhanced by their potential ability to provide a previously unexamined explanation for racial and gender disparities in aging health. The proposed project will draw on two ongoing complementary longitudinal datasets that focus on community-dwelling older individuals. Thus, we will pursue the following aims and hypotheses for the first time:
Aim 1 : Examine whether older individuals'age beliefs are associated with stress biomarkers over time. Hypothesis 1: Older individuals'negative age beliefs will predict elevated stress biomarkers over time.
Aim 2 : Examine whether racial and gender disparities exist in the influence of older individuals'age beliefs on stress biomarkers over time. Hypothesis 2a: Older African Americans will be more vulnerable than same-aged older whites to the adverse impact of negative age beliefs on stress biomarkers over time. Hypothesis 2b: Older women will be more vulnerable than same-aged older men to the adverse impact of negative age beliefs on stress biomarkers over time.
Aim 3 : Examine whether older individuals'stress biomarkers over time mediate the relationship between age beliefs and worse cognitive and physical health over time. Hypothesis 3: Older individuals'stress biomarkers will mediate the relationship between negative age beliefs and worse cognitive health (i.e., memory deficits, risk of mild cognitive impairment and Alzheimer's disease, and smaller hippocampal volume) and worse physical health (i.e., physical-function deficits, risk of cardiovascular events, and higher mortality) over time.
Aim 4 : Identify the factors that moderate negative age beliefs'influence on older individuals'stress biomarkers over time. Hypothesis 4: Resiliency factors (i.e. Feeling Useful to Others, Openness, and Emotional Stability) and vulnerability factors (i.e., Age-belief Self-relevance and Adverse Life Events) will moderate negative age beliefs'effect on stress biomarkers over time. This study could identify a new and potentially modifiable process, negative age beliefs'association with stress biomarkers over time, as a factor that contributes to adverse health outcomes among older individuals.

Public Health Relevance

Many individuals are bombarded with a variety of negative age beliefs, throughout their lifespans, that become associated with worse health in later life. The overall goal of the proposed project is to examine whether biological indicators of stress are the mechanism that explains the harmful effects of older individuals'negative age beliefs on their cognitive and physical health. The proposed project could provide the foundation for developing targeted interventions that improve the health of older individuals in general and older women and older African Americans in particular.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project (R01)
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Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Nielsen, Lisbeth
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Yale University
Public Health & Prev Medicine
Schools of Medicine
New Haven
United States
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Monin, Joan K; Mota, Natalie; Levy, Becca et al. (2017) Older Age Associated with Mental Health Resiliency in Sexual Minority US Veterans. Am J Geriatr Psychiatry 25:81-90
Weiner, Melissa R; Monin, Joan K; Mota, Natalie et al. (2016) Age Differences in the Association of Social Support and Mental Health in Male U.S. Veterans: Results From the National Health and Resilience in Veterans Study. Am J Geriatr Psychiatry 24:327-36
Monin, Joan; Doyle, Margaret; Levy, Becca et al. (2016) Spousal Associations Between Frailty and Depressive Symptoms: Longitudinal Findings from the Cardiovascular Health Study. J Am Geriatr Soc 64:824-30
Pietrzak, Robert H; Zhu, Yong; Slade, Martin D et al. (2016) Association Between Negative Age Stereotypes and Accelerated Cellular Aging: Evidence from Two Cohorts of Older Adults. J Am Geriatr Soc 64:e228-e230
Levy, Becca R; Bavishi, Avni (2016) Survival Advantage Mechanism: Inflammation as a Mediator of Positive Self-Perceptions of Aging on Longevity. J Gerontol B Psychol Sci Soc Sci :
Bavishi, Avni; Slade, Martin D; Levy, Becca R (2016) A chapter a day: Association of book reading with longevity. Soc Sci Med 164:44-48
Levy, Becca R; Ferrucci, Luigi; Zonderman, Alan B et al. (2016) A culture-brain link: Negative age stereotypes predict Alzheimer's disease biomarkers. Psychol Aging 31:82-8
Mitchell, Hannah-Rose; Levy, Becca R; Keene, Danya E et al. (2015) Reactivity to a Spouse's Interpersonal Suffering in Late Life Marriage: A Mixed-Methods Approach. J Aging Health 27:939-61
Monin, Joan K; Levy, Becca; Chen, Baibing et al. (2015) Husbands' and Wives' Physical Activity and Depressive Symptoms: Longitudinal Findings from the Cardiovascular Health Study. Ann Behav Med 49:704-14
Ng, Reuben; Allore, Heather G; Trentalange, Mark et al. (2015) Increasing negativity of age stereotypes across 200 years: evidence from a database of 400 million words. PLoS One 10:e0117086

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