Stress is part of daily life;in a national study 40% of respondents reported experiencing stress that day. We know from many studies that stress can affect health, memory, and well-being. But does it affect how we make decisions? And if so, what are the implications-do we become more or less risk averse? Are we more influenced by the potential downsides and less by potential upsides to an option than we would be otherwise? Making decisions involves a complex yet flexible set of brain mechanisms that compute the potential value of options and adjust that value based on the level of uncertainty about the outcome. In this proposal, we examine the effects of acute stress on the basic elements of decision making: the neural signals that predict and represent value, integrate the positive and negative aspects of options, and assess risk based on predicted volatility and uncertainty of options. We test two main hypotheses. The first is that stress makes rewarding stimuli even more attractive and salient, via dopaminergic effects in the ventral striatum. The second is that stress affects risk processing via the insula, but that it has different effects depending on one's sex and age. Some of our most important decisions must be made under stressful circumstances;thus it is paramount that we understand the basic mechanisms of how stress changes the way we evaluate decision options.

Public Health Relevance

Important decisions, such as those regarding personal finances and health care, often involve substantial stress, especially among older adults. The studies in this proposal will provide important information about how stress affects those decisions and how risk averse people are. Making optimal decisions is challenging even under the best of circumstances;these findings should provide critical information for understanding how to improve decision making under stress.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG038043-03
Application #
8286232
Study Section
Special Emphasis Panel (ZRG1-RPHB-A (91))
Program Officer
Nielsen, Lisbeth
Project Start
2010-07-01
Project End
2015-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
3
Fiscal Year
2012
Total Cost
$319,215
Indirect Cost
$122,169
Name
University of Southern California
Department
None
Type
Other Domestic Higher Education
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Mather, Mara; Harley, Carolyn W (2016) The Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain. Trends Cogn Sci 20:214-26
Barber, Sarah J; Opitz, Philipp C; Martins, Bruna et al. (2016) Thinking about a limited future enhances the positivity of younger and older adults' recall: Support for socioemotional selectivity theory. Mem Cognit 44:869-82
Clewett, David V; Lee, Tae-Ho; Greening, Steven et al. (2016) Neuromelanin marks the spot: identifying a locus coeruleus biomarker of cognitive reserve in healthy aging. Neurobiol Aging 37:117-26
Herrera, Alexandra Ycaza; Nielsen, Shawn E; Mather, Mara (2016) Stress-induced increases in progesterone and cortisol in naturally cycling women. Neurobiol Stress 3:96-104
Mather, Mara (2016) The Affective Neuroscience of Aging. Annu Rev Psychol 67:213-38
Barber, Sarah J; Mather, Mara; Gatz, Margaret (2015) How Stereotype Threat Affects Healthy Older Adults' Performance on Clinical Assessments of Cognitive Decline: The Key Role of Regulatory Fit. J Gerontol B Psychol Sci Soc Sci 70:891-900
Ycaza Herrera, Alexandra; Mather, Mara (2015) Actions and interactions of estradiol and glucocorticoids in cognition and the brain: Implications for aging women. Neurosci Biobehav Rev 55:36-52
Nielsen, Shawn E; Mather, Mara (2015) Comparison of two isometric handgrip protocols on sympathetic arousal in women. Physiol Behav 142:5-13
Nielsen, Shawn E; Barber, Sarah J; Chai, Audrey et al. (2015) Sympathetic arousal increases a negative memory bias in young women with low sex hormone levels. Psychoneuroendocrinology 62:96-106
Clewett, David; Bachman, Shelby; Mather, Mara (2014) Age-related reduced prefrontal-amygdala structural connectivity is associated with lower trait anxiety. Neuropsychology 28:631-42

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