Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG047116-01
Application #
8666121
Study Section
Special Emphasis Panel (ZAG1-ZIJ-6 (J3))
Program Officer
Petanceska, Suzana
Project Start
2013-09-01
Project End
2017-06-30
Budget Start
2013-09-01
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$441,176
Indirect Cost
$141,176
Name
University of California Santa Barbara
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
094878394
City
Santa Barbara
State
CA
Country
United States
Zip Code
93106
Economou, Nicholas J; Giammona, Maxwell J; Do, Thanh D et al. (2016) Amyloid β-Protein Assembly and Alzheimer's Disease: Dodecamers of Aβ42, but Not of Aβ40, Seed Fibril Formation. J Am Chem Soc 138:1772-5
Do, Thanh D; LaPointe, Nichole E; Nelson, Rebecca et al. (2016) Amyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels. J Am Chem Soc 138:549-57
Zheng, Xueyun; Wu, Chun; Liu, Deyu et al. (2016) Mechanism of C-Terminal Fragments of Amyloid β-Protein as Aβ Inhibitors: Do C-Terminal Interactions Play a Key Role in Their Inhibitory Activity? J Phys Chem B 120:1615-23
de Almeida, Natália E C; Do, Thanh D; Tro, Michael et al. (2016) Opposing Effects of Cucurbit[7]uril and 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranose on Amyloid β25-35 Assembly. ACS Chem Neurosci 7:218-26
Feinstein, H Eric; Benbow, Sarah J; LaPointe, Nichole E et al. (2016) Oligomerization of the microtubule-associated protein tau is mediated by its N-terminal sequences: implications for normal and pathological tau action. J Neurochem 137:939-54
Do, Thanh D; Chamas, Ali; Zheng, Xueyun et al. (2015) Elucidation of the Aggregation Pathways of Helix-Turn-Helix Peptides: Stabilization at the Turn Region Is Critical for Fibril Formation. Biochemistry 54:4050-62
Eschmann, Neil A; Do, Thanh D; LaPointe, Nichole E et al. (2015) Tau Aggregation Propensity Engrained in Its Solution State. J Phys Chem B 119:14421-32
Roychaudhuri, Robin; Zheng, Xueyun; Lomakin, Aleksey et al. (2015) Role of Species-Specific Primary Structure Differences in Aβ42 Assembly and Neurotoxicity. ACS Chem Neurosci 6:1941-55
Zheng, Xueyun; Liu, Deyu; Roychaudhuri, Robin et al. (2015) Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and Recessive A2V Familial Alzheimer's Disease Mutation. ACS Chem Neurosci 6:1732-40
Zheng, Xueyun; Liu, Deyu; Klärner, Frank-Gerrit et al. (2015) Amyloid β-protein assembly: The effect of molecular tweezers CLR01 and CLR03. J Phys Chem B 119:4831-41

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