Abstract

We are engaged in a systematic study of the subpopulations of lymphocytes engaged in the humoral and cellular immune response. We have developed a variety of techniques and reagents for the separation of these subpopulations and a number of assays for various lymphocyte functions. A major current interest is in the characterization of the immune response to allogeneic antigens of the major histocompatibility complex, and the study of the non antigen specific factors involved in cell interactions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI008795-17
Application #
3124453
Study Section
Immunobiology Study Section (IMB)
Project Start
1978-12-01
Project End
1987-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
17
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
Organized Research Units
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Thor, G; Sepulveda, H; Chada, S et al. (1993) Monoclonal antibody that distinguishes between a phosphorylated, beta 2-microglobulin-associated, and a free, nonphosphorylated, chain of MHC class I. J Immunol 151:211-24
Muralidhar, G; Sepulveda, H; Feeney, A J et al. (1992) Restricted IgH V gene usage in the response to the ese epitope on ""Hi"" sheep red blood cells. J Immunol 149:3574-9
Voland, J R; Wyzykowski, R J; Huang, M et al. (1992) Cloning and sequencing of a trophoblast-endothelial-activated lymphocyte surface protein: cDNA sequence and genomic structure. Proc Natl Acad Sci U S A 89:10425-9
Kubota, E; McKenzie, D T; Dutton, R W et al. (1991) Role of T cells in the B-cell response: glutaraldehyde-fixed T-helper hybridoma cells synergize with the lymphokine IL-4 to induce B-cell activation and proliferation. Immunology 72:40-7
Tonkonogy, S L; McKenzie, D T; Swain, S L (1989) Regulation of isotype production by IL-4 and IL-5. Effects of lymphokines on Ig production depend on the state of activation of the responding B cells. J Immunol 142:4351-60
Southern, S O; Dutton, R W (1989) A role for class I MHC antigens in responses of activated B lymphocytes. J Immunol 142:3384-91
Swain, S L; Dutton, R W; McKenzie, D et al. (1988) Role of antigen in the B cell response. Specific antigen and the lymphokine IL-5 synergize to drive B cell lymphoma proliferation and differentiation to Ig secretion. J Immunol 140:4224-30
Tonkonogy, S L; Swain, S L (1988) Stimulation of gut-associated lymphoid cells by IL-4 and B-cell growth factor II. Immunology 64:155-61
McKenzie, D (1988) Alloantigen presentation by B cells. Requirement for IL-1 and IL-6. J Immunol 141:2907-11
Swain, S L; Dutton, R W (1987) B cell growth factor interactions. Adv Exp Med Biol 213:215-25

Showing the most recent 10 out of 15 publications