Abstract

The aims of the project are 1) To expand information on the disease-producing potential of JC virus and BK virus in extraneural tissues and on sites of latent infection by these viruses. Children with urinary tract infections and immunosuppressed persons with interstitial pneumonia will be studied; 2) To continue development of information about the role of JC virus in progressive multifocal leukoencephalopathy. Virus isolated from diseased brain tissue will be compared with virus from other sources. Viral proteins will be studied; 3) To isolate and characterize new human polyomaviruses; 4) To continue development of information about the oncogenicity of JCV.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI011217-13
Application #
3124923
Study Section
Virology Study Section (VR)
Project Start
1978-06-01
Project End
1988-05-31
Budget Start
1985-06-01
Budget End
1988-05-31
Support Year
13
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Cheng, R H; Kuhn, R J; Olson, N H et al. (1995) Nucleocapsid and glycoprotein organization in an enveloped virus. Cell 80:621-30
Tavis, J E; Frisque, R J; Walker, D L et al. (1990) Antigenic and transforming properties of the DB strain of the human polyomavirus BK virus. Virology 178:568-72
Tavis, J E; Walker, D L; Gardner, S D et al. (1989) Nucleotide sequence of the human polyomavirus AS virus, an antigenic variant of BK virus. J Virol 63:901-11
Haggerty, S; Walker, D L; Frisque, R J (1989) JC virus-simian virus 40 genomes containing heterologous regulatory signals and chimeric early regions: identification of regions restricting transformation by JC virus. J Virol 63:2180-90
Rhodes, R H; Ward, J M; Walker, D L et al. (1988) Progressive multifocal leukoencephalopathy and retroviral encephalitis in acquired immunodeficiency syndrome. Arch Pathol Lab Med 112:1207-13
Rubino, M J; Walker, D (1988) Immunosuppression and murine polyomavirus infection. Virus Res 9:1-10
Mandl, C; Walker, D L; Frisque, R J (1987) Derivation and characterization of POJ cells, transformed human fetal glial cells that retain their permissivity for JC virus. J Virol 61:755-63
Stoner, G L; Ryschkewitsch, C F; Walker, D L et al. (1986) Immunocytochemical search for JC papovavirus large T-antigen in multiple sclerosis brain tissue. Acta Neuropathol 70:345-7
Stoner, G L; Ryschkewitsch, C F; Walker, D L et al. (1986) JC papovavirus large tumor (T)-antigen expression in brain tissue of acquired immune deficiency syndrome (AIDS) and non-AIDS patients with progressive multifocal leukoencephalopathy. Proc Natl Acad Sci U S A 83:2271-5
Chuke, W F; Walker, D L; Peitzman, L B et al. (1986) Construction and characterization of hybrid polyomavirus genomes. J Virol 60:960-71