Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI018289-15
Application #
2060674
Study Section
Virology Study Section (VR)
Project Start
1981-09-30
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Dentistry
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Atanasiu, Doina; Saw, Wan Ting; Lazear, Eric et al. (2018) Using Antibodies and Mutants To Localize the Presumptive gH/gL Binding Site on Herpes Simplex Virus gD. J Virol 92:
Hook, Lauren M; Cairns, Tina M; Awasthi, Sita et al. (2018) Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs. PLoS Pathog 14:e1007095
Hensel, Michael T; Marshall, Jason D; Dorwart, Michael R et al. (2017) Prophylactic Herpes Simplex Virus 2 (HSV-2) Vaccines Adjuvanted with Stable Emulsion and Toll-Like Receptor 9 Agonist Induce a Robust HSV-2-Specific Cell-Mediated Immune Response, Protect against Symptomatic Disease, and Reduce the Latent Viral Reservoir. J Virol 91:
Cairns, Tina M; Ditto, Noah T; Lou, Huan et al. (2017) Global sensing of the antigenic structure of herpes simplex virus gD using high-throughput array-based SPR imaging. PLoS Pathog 13:e1006430
Fontana, Juan; Atanasiu, Doina; Saw, Wan Ting et al. (2017) The Fusion Loops of the Initial Prefusion Conformation of Herpes Simplex Virus 1 Fusion Protein Point Toward the Membrane. MBio 8:
Atanasiu, Doina; Saw, Wan Ting; Eisenberg, Roselyn J et al. (2016) Regulation of HSV glycoprotein induced cascade of events governing cell-cell fusion. J Virol :
Persson, Josefine; Zhang, Yuan; Olafsdottir, Thorunn A et al. (2016) Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs. Front Immunol 7:640
Cairns, Tina M; Huang, Zhen-Yu; Gallagher, John R et al. (2015) Patient-Specific Neutralizing Antibody Responses to Herpes Simplex Virus Are Attributed to Epitopes on gD, gB, or Both and Can Be Type Specific. J Virol 89:9213-31
Saw, Wan Ting; Matsuda, Zene; Eisenberg, Roselyn J et al. (2015) Using a split luciferase assay (SLA) to measure the kinetics of cell-cell fusion mediated by herpes simplex virus glycoproteins. Methods 90:68-75
Whitbeck, J Charles; Huang, Zhen-Yu; Cairns, Tina M et al. (2014) Repertoire of epitopes recognized by serum IgG from humans vaccinated with herpes simplex virus 2 glycoprotein D. J Virol 88:7786-95

Showing the most recent 10 out of 93 publications