Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI019838-13
Application #
2061039
Study Section
Virology Study Section (VR)
Project Start
1983-04-01
Project End
1997-03-31
Budget Start
1995-04-01
Budget End
1997-03-31
Support Year
13
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Lawler, Jessica L; Mukherjee, Purba; Coen, Donald M (2018) Herpes Simplex Virus 1 DNA Polymerase RNase H Activity Acts in a 3'-to-5' Direction and Is Dependent on the 3'-to-5' Exonuclease Active Site. J Virol 92:
Beelontally, Rooksarr; Wilkie, Gavin S; Lau, Betty et al. (2017) Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins. Antiviral Res 138:61-67
Strang, Blair L (2017) RO0504985 is an inhibitor of CMGC kinase proteins and has anti-human cytomegalovirus activity. Antiviral Res 144:21-26
Chen, Han; Coseno, Molly; Ficarro, Scott B et al. (2017) A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions. ACS Infect Dis 3:112-118
Khan, Amina S; Murray, Matthew J; Ho, Catherine M K et al. (2017) High-throughput screening of a GlaxoSmithKline protein kinase inhibitor set identifies an inhibitor of human cytomegalovirus replication that prevents CREB and histone H3 post-translational modification. J Gen Virol 98:754-768
Wilkie, Adrian R; Lawler, Jessica L; Coen, Donald M (2016) A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress. MBio 7:
Chen, Han; Li, Chengwei; Zemlicka, Jiri et al. (2016) Potency and Stereoselectivity of Cyclopropavir Triphosphate Action on Human Cytomegalovirus DNA Polymerase. Antimicrob Agents Chemother 60:4176-82
Polachek, William S; Moshrif, Hanan F; Franti, Michael et al. (2016) High-Throughput Small Interfering RNA Screening Identifies Phosphatidylinositol 3-Kinase Class II Alpha as Important for Production of Human Cytomegalovirus Virions. J Virol 90:8360-71
Chen, Han; Beardsley, G Peter; Coen, Donald M (2014) Mechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activity. Proc Natl Acad Sci U S A 111:17462-7
Terrell, Shariya L; Pesola, Jean M; Coen, Donald M (2014) Roles of conserved residues within the pre-NH2-terminal domain of herpes simplex virus 1 DNA polymerase in replication and latency in mice. J Gen Virol 95:940-7

Showing the most recent 10 out of 87 publications