Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI028339-03S1
Application #
2064384
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1993-09-30
Project End
1998-06-30
Budget Start
1996-09-01
Budget End
1998-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Pediatrics
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Xiao, Tony Z; Singh, Kanal; Dunn, Elizabeth et al. (2012) T cell and B Cell immunity can be reconstituted with mismatched hematopoietic stem cell transplantation without alkylator therapy in artemis-deficient mice using anti-natural killer cell antibody and photochemically treated sensitized donor T cells. Biol Blood Marrow Transplant 18:200-9
Xiao, Zheng; Dunn, Elizabeth; Singh, Kanal et al. (2009) A non-leaky Artemis-deficient mouse that accurately models the human severe combined immune deficiency phenotype, including resistance to hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 15:1-11
Povirk, Lawrence F; Zhou, Tong; Zhou, Ruizhe et al. (2007) Processing of 3'-phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease. J Biol Chem 282:3547-58
Li, Lanying; Salido, Eduardo; Zhou, Yungui et al. (2005) Targeted disruption of the Artemis murine counterpart results in SCID and defective V(D)J recombination that is partially corrected with bone marrow transplantation. J Immunol 174:2420-8
Wang, Junhua; Pluth, Janice M; Cooper, Priscilla K et al. (2005) Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. DNA Repair (Amst) 4:556-70
Li, Lanying; Moshous, Despina; Zhou, Yungui et al. (2002) A founder mutation in Artemis, an SNM1-like protein, causes SCID in Athabascan-speaking Native Americans. J Immunol 168:6323-9
Li, Lanying; Zhou, Yungui; Wang, Junhua et al. (2002) Prenatal diagnosis and carrier detection for Athabascan severe combined immunodeficiency disease. Prenat Diagn 22:763-8
O'Marcaigh, A S; DeSantes, K; Hu, D et al. (2001) Bone marrow transplantation for T-B- severe combined immunodeficiency disease in Athabascan-speaking native Americans. Bone Marrow Transplant 27:703-9
Denianke, K S; Frieden, I J; Cowan, M J et al. (2001) Cutaneous manifestations of maternal engraftment in patients with severe combined immunodeficiency: a clinicopathologic study. Bone Marrow Transplant 28:227-33
Moshous, D; Li, L; Chasseval, R et al. (2000) A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p. Hum Mol Genet 9:583-8

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