Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI033063-05
Application #
2068041
Study Section
Experimental Virology Study Section (EVR)
Project Start
1992-07-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1998-04-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Awasthi, Sita; Zumbrun, Elizabeth E; Si, Huaxin et al. (2012) Live attenuated herpes simplex virus 2 glycoprotein E deletion mutant as a vaccine candidate defective in neuronal spread. J Virol 86:4586-98
Lubinski, John M; Lazear, Helen M; Awasthi, Sita et al. (2011) The herpes simplex virus 1 IgG fc receptor blocks antibody-mediated complement activation and antibody-dependent cellular cytotoxicity in vivo. J Virol 85:3239-49
Haugo, Alison C; Szpara, Moriah L; Parsons, Lance et al. (2011) Herpes simplex virus 1 pUL34 plays a critical role in cell-to-cell spread of virus in addition to its role in virus replication. J Virol 85:7203-15
Szpara, Moriah L; Tafuri, Yolanda R; Parsons, Lance et al. (2011) A wide extent of inter-strain diversity in virulent and vaccine strains of alphaherpesviruses. PLoS Pathog 7:e1002282
Huang, Jialing; Lazear, Helen M; Friedman, Harvey M (2011) Completely assembled virus particles detected by transmission electron microscopy in proximal and mid-axons of neurons infected with herpes simplex virus type 1, herpes simplex virus type 2 and pseudorabies virus. Virology 409:12-6
Wang, Fushan; Zumbrun, Elizabeth E; Huang, Jialing et al. (2010) Herpes simplex virus type 2 glycoprotein E is required for efficient virus spread from epithelial cells to neurons and for targeting viral proteins from the neuron cell body into axons. Virology 405:269-79
Szpara, Moriah L; Parsons, Lance; Enquist, L W (2010) Sequence variability in clinical and laboratory isolates of herpes simplex virus 1 reveals new mutations. J Virol 84:5303-13
McGraw, Helen M; Awasthi, Sita; Wojcechowskyj, Jason A et al. (2009) Anterograde spread of herpes simplex virus type 1 requires glycoprotein E and glycoprotein I but not Us9. J Virol 83:8315-26
King, Ryan D; Lubinski, John M; Friedman, Harvey M (2009) Herpes simplex virus type 1 infection increases the carbohydrate binding activity and the secretion of cellular galectin-3. Arch Virol 154:609-18
McGraw, Helen M; Friedman, Harvey M (2009) Herpes simplex virus type 1 glycoprotein E mediates retrograde spread from epithelial cells to neurites. J Virol 83:4791-9

Showing the most recent 10 out of 16 publications