: Malaria is the most deadly disease in the populous highlands of Kenya. Efforts to prevent and control malaria epidemics have been limited due to our inadequate understanding of malaria transmission mechanisms. The proposed research will use an interdisciplinary approach to examine the mechanisms leading to the resurgence of highland malaria in Kakamega and Kisii districts, western Kenya. Our hypothesis is that malaria epidemics in the highlands arise because land use changes have significantly altered the microhabitats and microclimatic conditions of vector mosquitoes and the malaria parasite, making local malaria transmission possible in previously unsuitable areas. The proposed research has three specific aims. First, current landuse patterns and recent changes will be examined, through field surveys and satellite image analysis, and the impact of land use changes on mosquito microhabitats and microclimatic conditions will be evaluated. Second, experiments will be conducted to determine whether changes in mosquito habitats and microclimatic conditions increase mosquito vectorial capacity by enhancing mosquito survivorship, shortening the development time of the malaria parasite, and increasing mosquito blood feeding frequency. Third, spatially explicit malaria transmission models will be developed and validated, with a particular emphasis on the effects of land use and microclimate changes. A differential-equation compartment model will be developed to predict threshold densities of vectors, below which epidemics cannot occur, and a spatial stochastic model will be developed to predict malaria risks in heterogeneous environments. The generalizability and prediction accuracy of the models will be tested. This project is innovative in 2 aspects. First, this will be the first detailed study of relationships between land use changes and malaria transmission in the African highlands. Second, this will be the first study to model malaria transmission using a spatial epidemiological modeling approach. We anticipate that our results will have broad application to malaria prevention and control in African.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI050243-01
Application #
6370901
Study Section
Special Emphasis Panel (ZRG1-TMP (01))
Program Officer
Aultman, Kathryn S
Project Start
2001-09-01
Project End
2006-06-30
Budget Start
2001-09-01
Budget End
2002-06-30
Support Year
1
Fiscal Year
2001
Total Cost
$614,447
Indirect Cost
Name
State University of New York at Buffalo
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
Koepfli, Cristian; Yan, Guiyun (2018) Plasmodium Gametocytes in Field Studies: Do We Measure Commitment to Transmission or Detectability? Trends Parasitol 34:378-387
Derua, Yahya A; Kahindi, Samuel C; Mosha, Franklin W et al. (2018) Microbial larvicides for mosquito control: Impact of long lasting formulations of Bacillus thuringiensis var. israelensis and Bacillus sphaericus on non-target organisms in western Kenya highlands. Ecol Evol 8:7563-7573
Hemming-Schroeder, Elizabeth; Strahl, Stephanie; Yang, Eugene et al. (2018) Emerging Pyrethroid Resistance among Anopheles arabiensis in Kenya. Am J Trop Med Hyg 98:704-709
Kapesa, Anthony; Kweka, Eliningaya J; Zhou, Guofa et al. (2018) Utility of passive malaria surveillance in hospitals as a surrogate to community infection transmission dynamics in western Kenya. Arch Public Health 76:39
Aidoo, Ebenezer K; Afrane, Yaw A; Machani, Maxwell Gesuge et al. (2018) Reactive case detection of Plasmodium falciparum in western Kenya highlands: effective in identifying additional cases, yet limited effect on transmission. Malar J 17:111
Hemming-Schroeder, Elizabeth; Umukoro, Emuejevuoke; Lo, Eugenia et al. (2018) Impacts of Antimalarial Drugs on Plasmodium falciparum Drug Resistance Markers, Western Kenya, 2003-2015. Am J Trop Med Hyg 98:692-699
Zemene, Endalew; Koepfli, Cristian; Tiruneh, Abebaw et al. (2018) Detection of foci of residual malaria transmission through reactive case detection in Ethiopia. Malar J 17:390
Zhong, Daibin; Lo, Eugenia; Wang, Xiaoming et al. (2018) Multiplicity and molecular epidemiology of Plasmodium vivax and Plasmodium falciparum infections in East Africa. Malar J 17:185
Kapesa, Anthony; Kweka, Eliningaya J; Atieli, Harrysone et al. (2018) The current malaria morbidity and mortality in different transmission settings in Western Kenya. PLoS One 13:e0202031
Kahindi, Samuel C; Muriu, Simon; Derua, Yahya A et al. (2018) Efficacy and persistence of long-lasting microbial larvicides against malaria vectors in western Kenya highlands. Parasit Vectors 11:438

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