There were two types of setbacks to this R01 project. Lab staff lost 2 months of work as will be explained and material were destroyed in cold rooms and some refrigerators that failed due to insufficient emergency power early in the outage. The full closure of the Skirball Institute for 2 weeks caused a disruption of work that resulted in loss of experiments started up on 2 weeks prior to the storm on Oct 29 and required an additional month to fully recover cell cultures and reagents to resume experiments.

Public Health Relevance

Vaccination strategies depend upon a physical embrace between antigen specific T lymphocytes and antigen presenting dendritic cells. We hypothesize that the stability of this embrace will depend upon the quality of antigen that defines a stop signal for the migrating T cell; signals in the environment that provide a competing go signal to the lymphocyte and polarity networks controlled by kinases. We propose experiments to determine the roles of chemokines; dendritic cell frequency and regulatory T cell protein kinase C-8 in tolerance induction.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI055037-10S1
Application #
8673598
Study Section
Special Emphasis Panel (ZRG1 (02))
Program Officer
Lapham, Cheryl K
Project Start
2014-01-24
Project End
2016-01-23
Budget Start
2014-01-24
Budget End
2016-01-23
Support Year
10
Fiscal Year
2014
Total Cost
$60,294
Indirect Cost
$24,722
Name
New York University
Department
Pathology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
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Matsumura, Satoko; Wang, Baomei; Kawashima, Noriko et al. (2008) Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol 181:3099-107

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