Viruses Strategies for control of influenza and other respiratory infections have been based on models using assumptions derived from the Tecumseh Study of Respiratory Illness, conducted 30 years ago. Since that time, laboratory and analytic methods have markedly advanced. We have recruited more than 300 households with children for a longitudinal study of respiratory illnesses. We propose to determine the incidence and characteristics of respiratory infections by collecting specimens from subjects with respiratory illness meeting a case definition, and testing specimens using PCR to identify influenza and other respiratory viruses. To determine susceptibility to influenza, and immunologic response to infection and vaccination, blood specimens will be collected at three points annually, and tested in hemagglutination inhibition (HAI), microneutralization and other assays to measure influenza specific antibody titers and changes in titers between specimens. Both standard techniques and dynamic transmission models will be used in data analysis. Household infection rates and the effects of crowding and humidity will be determined. Secondary spread, conditioned on susceptibility will be calculated. Transmission in schools and the overall community will be compared with those in the household. Results will provide an updated scientific basis for determining control strategies.

Public Health Relevance

Understanding the occurrence of influenza and other respiratory viruses and how they are transmitted is essential for successful control. We propose to study these illnesses in households with children and use the collected data to identify factors involved in transmission, in the household and community, using a variety of analytic techniques.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI097150-02
Application #
8531142
Study Section
Clinical Research and Field Studies of Infectious Diseases Study Section (CRFS)
Program Officer
Stemmy, Erik J
Project Start
2012-08-20
Project End
2016-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
2
Fiscal Year
2013
Total Cost
$451,200
Indirect Cost
$161,039
Name
University of Michigan Ann Arbor
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Malosh, Ryan; Ohmit, Suzanne E; Petrie, Joshua G et al. (2014) Factors associated with influenza vaccine receipt in community dwelling adults and their children. Vaccine 32:1841-7
Monto, Arnold S; Malosh, Ryan E; Petrie, Joshua G et al. (2014) Frequency of acute respiratory illnesses and circulation of respiratory viruses in households with children over 3 surveillance seasons. J Infect Dis 210:1792-9