Morbidity and mortality of human newborns are significant public health concerns. Predominant risk factors for neonatal morbidity and mortality are invasive bacterial infections and the ensuing severe inflammatory response, which mainly begin in utero. Group B Streptococci (GBS) are a significant cause of preterm births, stillbirths and early onset neonatal disease. Factors that facilitate ascending GBS infection from the lower genital tract to the fetus are not understood. Our studies indicate that upregulation of virulence factors facilitate GBS invasion of placental membranes in vitro. Using human placental membranes and a nonhuman primate model, the objective of this proposal is to mechanistically define how virulence factors enable ascending in utero GBS infection and subsequent fetal lung and brain injury.
Understanding mechanisms of ascending GBS infection and fetal injury will be beneficial for development of therapeutic strategies against in utero infectios that lead to fetal injury, preterm births, and stillbirths.
|Harrell, Maria I; Burnside, Kellie; Whidbey, Christopher et al. (2017) Exploring the Pregnant Guinea Pig as a Model for Group B Streptococcus Intrauterine Infection. J Infect Dis Med 2:|
|Li, Junwei; Baird, Madison A; Davis, Michael A et al. (2017) Dramatic enhancement of the detection limits of bioassays via ultrafast deposition of polydopamine. Nat Biomed Eng 1:|
|Vornhagen, Jay; Adams Waldorf, Kristina M; Rajagopal, Lakshmi (2017) Perinatal Group B Streptococcal Infections: Virulence Factors, Immunity, and Prevention Strategies. Trends Microbiol 25:919-931|
|Gendrin, Claire; Shubin, Nicholas J; Boldenow, Erica et al. (2017) Mast cell chymase decreases the severity of group B Streptococcus infections. J Allergy Clin Immunol :|
|Gendrin, Claire; Vornhagen, Jay; Armistead, Blair et al. (2017) A non-hemolytic Group B Streptococcus strain exhibits hypervirulence. J Infect Dis :|
|Vornhagen, Jay; Quach, Phoenicia; Boldenow, Erica et al. (2016) Bacterial Hyaluronidase Promotes Ascending GBS Infection and Preterm Birth. MBio 7:|
|Adams Waldorf, Kristina M; Stencel-Baerenwald, Jennifer E; Kapur, Raj P et al. (2016) Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate. Nat Med 22:1256-1259|
|Boldenow, Erica; Gendrin, Claire; Ngo, Lisa et al. (2016) Group B Streptococcus circumvents neutrophils and neutrophil extracellular traps during amniotic cavity invasion and preterm labor. Sci Immunol 1:|
|Gendrin, Claire; Vornhagen, Jay; Ngo, Lisa et al. (2015) Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection. Sci Adv 1:e1400225|
|Gendrin, Claire; Lembo, Annalisa; Whidbey, Christopher et al. (2015) The sensor histidine kinase RgfC affects group B streptococcal virulence factor expression independent of its response regulator RgfA. Infect Immun 83:1078-88|
Showing the most recent 10 out of 22 publications