About 12% of young adults will meet the criteria for chronic fatigue syndrome (CFS) 6 months following infectious mononucleosis (IM) (Katz et al., 2011). IM appears to be a predisposing factor for some individuals who develop CFS. Many candidate psychological and biological risk factors have been proposed to explain this phenomenon, but almost all lack prospective data from before the patients became ill with either IM or CFS. Some students develop IM while in college. Many student health services have students who use their services when they are medically well (e.g., for sports-related injuries and birth control). Our study will enroll Northwestern University (NU) students who use the university based health services when medically well, as well as after they develop IM and CFS. We will gather biological and psychological data when students are well, when they develop IM, and when they develop CFS. At the end of the 3 year recruitment period, we will continue to follow those who have developed CFS for 12 months. We will collect data regarding candidate biological and psychological factors thought to be related to the development of CFS, such as previous stressful life events, action proneness, coping skills, autonomic dysfunction, cytokine levels and the severity of the IM itself. Our proposed study will compare these prospective pre-illness (IM) variables to post-illness (IM) data between students who do and do not go on to develop CFS. This study will be able to identify risk factors for the development of CFS following IM. We have the unique ability to implement this prospective study with a captive and high-risk population for the development of IM and CFS.

Public Health Relevance

The main purpose of this prospective study is to investigate biological and/or psychological factors present in young adults predict who will go on to develop CFS following IM. Identification of risk factors predisposing patients towards developing CFS may help to understand the underlying mechanisms of this illness.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI105781-04
Application #
9181376
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Beisel, Christopher E
Project Start
2013-12-01
Project End
2018-11-30
Budget Start
2016-12-01
Budget End
2017-11-30
Support Year
4
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Children's Memorial Hospital (Chicago)
Department
Type
DUNS #
074438755
City
Chicago
State
IL
Country
United States
Zip Code
60611
Sunnquist, Madison; Nicholson, Laura; Jason, Leonard A et al. (2017) Access to Medical Care for Individuals with Myalgic Encephalomyelitis and Chronic Fatigue Syndrome: A Call for Centers of Excellence. Mod Clin Med Res 1:28-35
Jason, Leonard A; McManimen, Stephanie; Sunnquist, Madison et al. (2017) Clinical Criteria Versus a Possible Research Case Definition in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. Fatigue 5:89-102
Sunnquist, Madison; Jason, Leonard A; Nehrke, Pamela et al. (2017) A Comparison of Case Definitions for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome. J Chronic Dis Manag 2:
Stoothoff, Jamie; Gleason, Kristen; McManimen, Stephanie et al. (2017) Subtyping Patients with Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS) By Course of Illness. J Biosens Biomark Diagn 2:
McManimen, Stephanie L; Jason, Leonard A (2017) Differences in ME and CFS Symptomology in Patients with Normal and Abnormal Exercise Test Results. Int J Neurol Neurother 4:
Jason, Leonard A; Katz, Ben; Gleason, Kristen et al. (2017) A Prospective Study of Infectious Mononucleosis in College Students. Int J Psychiatry (Overl Park) 2:
McManimen, Stephanie L; Jason, Leonard A (2017) Post-Exertional Malaise in Patients with ME and CFS with Comorbid Fibromyalgia. SRL Neurol Neurosurg 3:22-27
Jason, Leonard A; McManimen, Stephanie; Sunnquist, Madison et al. (2016) Case definitions integrating empiric and consensus perspectives. Fatigue 4:1-23
Kidd, Elizabeth; Brown, Abigail; McManimen, Stephanie et al. (2016) The Relationship between Age and Illness Duration in Chronic Fatigue Syndrome. Diagnostics (Basel) 6:
Williams-Harmon, Yolonda J; Jason, Leonard A; Katz, Ben Z (2016) Incidence of Infectious Mononucleosis in Universities and U.S. Military Settings. J Diagn Tech Biomed Anal 5:

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