Morbidity and mortality of human newborns remain significant public health concerns. Streptococcus agalactiae or Group B Streptococcus (GBS) cause invasive infections such as pneumonia, sepsis and meningitis in human newborns. Moreover, GBS are a significant cause of in utero infections leading to preterm births and stillbirths. We recently showed that the pluripotent toxin important for GBS infections is an ornithine rhamnolipid pigment also known as granadaene. The pigment/lipid toxin is cytotoxic to a number of host cells and induces a proinflammatory immune response. The objective of this proposal is to understand how the pigment causes host cell lysis and induces an immune response and to also define how pigment mediated activation of host cells affects GBS colonization and infection-associated preterm births.

Public Health Relevance

Understanding how the pigment/lipid toxin activates an immune response and causes host cell lysis will be valuable for the development of therapeutic strategies that prevent Group B Streptococcal infections in humans.

Agency
National Institute of Health (NIH)
Type
Research Project (R01)
Project #
1R01AI112619-01
Application #
8745832
Study Section
Bacterial Pathogenesis Study Section (BACP)
Program Officer
GU, Xin-Xing
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Seattle Children's Hospital
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98121