Abstract

The primary aim of this project will be continued study of the allograft problem. Studies of factors influencing transplant survival will utilize an extensive data base collected over the past 12 years and analyses will be done using an on-site computer facility. Factors to be examined include HLA-DR histocompatibility matching, possible enhancing antibodies, and the transfusion effect. Efforts will be made to devise means by which enhancing antibodies induced by transfusiuons can be detected. Sera from patients who subsequently reject grafts will be compared to those with successful grafts. Antimmunoglobulin antibodies are the principal antibodies postulated to be enhancing antibodies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Research Project (R01)
Project #
5R01AM002375-27
Application #
3150689
Study Section
Immunobiology Study Section (IMB)
Project Start
1976-12-01
Project End
1986-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
27
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Terasaki, P I; Cecka, J M; Gjertson, D W et al. (1995) High survival rates of kidney transplants from spousal and living unrelated donors. N Engl J Med 333:333-6
Mickey, M R; Cook, D J; Terasaki, P I (1989) Recipient pool sizes for prioritized HLA matching. Transplantation 47:401-3
Mickey, M R; Lau, M; Carnahan, B et al. (1989) Improved crossmatch prediction with DTT-treated sera. Transplant Proc 21:722-3
Cecka, J M; Cook, D J (1989) Optimal use of cadaver donor kidneys: high-risk donors and low-risk recipients. Transplant Proc 21:1417-8
Takiff, H; Iwaki, Y; Cecka, M et al. (1989) The benefit and underutilization of sharing kidneys for better histocompatibility. Transplantation 47:102-5
Cecka, J M; Cicciarelli, J; Mickey, M R et al. (1988) Blood transfusions and HLA matching--an either/or situation in cadaveric renal transplantation. Transplantation 45:81-6
Takiff, H; Novak, M; Iwaki, Y et al. (1988) Low-dose cyclosporine maintenance therapy after immunosuppressive induction in a rat cardiac transplant model. Transplantation 45:297-301
Takiff, H; Cook, D J; Himaya, N S et al. (1988) Dominant effect of histocompatibility on ten-year kidney transplant survival. Transplantation 45:410-5
Mickey, M R; Berne, T V; Kahan, B D et al. (1987) HLA matching assessed from early graft function. Transplant Proc 19:681-2
Iwaki, Y; Cook, D J; Terasaki, P I et al. (1987) Flow cytometry crossmatching in human cadaver kidney transplantation. Transplant Proc 19:764-6

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