Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR032007-14
Application #
2078795
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1983-03-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Schools of Pharmacy
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Kuzmic, P (1996) Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. Anal Biochem 237:260-73
Kuzmic, P; Peranteau, A G; Garcia-Echeverria, G et al. (1996) Mechanical effects on the kinetics of the HIV proteinase deactivation. Biochem Biophys Res Commun 221:313-7
Hu, M K; Badger, A; Rich, D H (1995) Cyclosporin analogs modified in the 3,7,8-positions: substituent effects on peptidylprolyl isomerase inhibition and immunosuppressive activity are nonadditive. J Med Chem 38:4164-70
Bartz, S R; Hohenwalter, E; Hu, M K et al. (1995) Inhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin A. Proc Natl Acad Sci U S A 92:5381-5
Peranteau, A G; Kuzmic, P; Angell, Y et al. (1995) Increase in fluorescence upon the hydrolysis of tyrosine peptides: application to proteinase assays. Anal Biochem 227:242-5
Kuzmic, P; Garcia-Echeverria, C; Rich, D H (1993) Stabilization of HIV proteinase dimer by bound substrate. Biochem Biophys Res Commun 194:301-5
Garcia-Echeverria, C; Kofron, J L; Kuzmic, P et al. (1993) A continuous spectrophotometric direct assay for peptidyl prolyl cis-trans isomerases. Biochem Biophys Res Commun 191:70-5
Kuzmic, P (1993) Kinetic assay for HIV proteinase subunit dissociation. Biochem Biophys Res Commun 191:998-1003
Moss, M L; Palmer, R E; Kuzmic, P et al. (1992) Identification of actin and HSP 70 as cyclosporin A binding proteins by photoaffinity labeling and fluorescence displacement assays. J Biol Chem 267:22054-9
Kuzmic, P; Moss, M L; Kofron, J L et al. (1992) Fluorescence displacement method for the determination of receptor-ligand binding constants. Anal Biochem 205:65-9

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