Two hundred healthy women between ages 20 and 25 will be recruited from the first year classes in the Creighton University Schools of Medicine, Dentistry and Law. Each will be observed for a period of four years in order to test the hypothesis that calcium intake measurably influences the peak adult bone mass achieved after cessation of growth. The effect of other nutrients such as protein, phosphorus, alcohol and caffeine on this consolidation of bone mass will also be tested along with the effect of various self-chosen levels of physical activity. Dietary evaluations will be made at three-month intervals throughout the study and bone mass measurements by radio-grammetry, single photon absorptiometry and dual photon absorptiometry will be made at six-month intervals. Physical activity will be measured at six-month intervals using an activity monitor worn on the wrist for a seven-day period. We hope to confirm the findings of other studies of increased bone mass occurring after cessation of linear growth and to define the determinants of this increased mass. Thus, we hope to be able to show that peak skeletal mass is influenced by non-genetic factors, amenable to intervention early in life in a manner that can result in higher skeletal mass prior at the time when age-related bone loss begins at about age 40. This could result in greater skeletal mass remaining in old age and could offer protection from the crippling fractures of postmenopausal osteoporosis which afflicts nearly one half of our Caucasian women in their later years.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR032462-03
Application #
3156309
Study Section
General Medicine B Study Section (GMB)
Project Start
1984-06-01
Project End
1989-05-31
Budget Start
1986-06-01
Budget End
1987-05-31
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Creighton University
Department
Type
Schools of Medicine
DUNS #
City
Omaha
State
NE
Country
United States
Zip Code
68178
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Davies, K M; Recker, R R; Stegman, M R et al. (1991) Tallness versus shrinkage: do women shrink with age or grow taller with recent birth date? J Bone Miner Res 6:1115-20
Heaney, R P; Davies, K M; Recker, R R et al. (1990) Long-term consistency of nutrient intakes in humans. J Nutr 120:869-75
Heaney, R P; Weaver, C M; Fitzsimmons, M L (1990) Influence of calcium load on absorption fraction. J Bone Miner Res 5:1135-8
Heaney, R P; Recker, R R; Weaver, C M (1990) Absorbability of calcium sources: the limited role of solubility. Calcif Tissue Int 46:300-4