Few strategies to prevent disease progression and disability in the setting of knee osteoarthritis (OA) exist, large part due to limited knowledge of the factors responsible for these outcomes. This deficiency of knowledge not only hinders development of novel strategies that target these factors, it also clouds our ability to identify individuals who are unlikely to benefit from a given prevention approach. The broad goal of our work is to identify the factors that contribute to OA disease progression and functional status decline the goal of the proposed study is to examine the relationship of 3 local joint-organ factors with 2-year disease progression and functional decline in a cohort of 300 subjects with knee OA: strength, within subsets of OA knees; medial and lateral laxity; and limb position sense during a locomotor task, ergometer pedaling. Progression will be assessed using both radiographic and MRI-based measures, and functional decline using observed and self-report measures The proposed infrastructure. Since 1997, we have been studying a cohort of subjects with knee OA. In this natural history study (MAK, the study of Mechanical Factors in Arthritis of the Knee), time 0 and 1.5 year visits are completed and 3 year visits are ongoing. The ongoing MAK study includes radiographic and functional assessments, but no MRI. Support for components of the next phase of this study to occur 2002-2007, including MRI evaluations, has been procured, substantially reducing the cost required to examine the questions posed in the current proposal. The 2 visits of the proposed study will occur at 5 (the first of the proposed study and 7 years on the MAK timeline. Strength, laxity, and joint position sense may each influence both structural and functional outcome of as vv t knee 0A. I He proposed study will provide important information regarding these factors that will be directly applicable to the development of strategies to prevent disease progression and disability.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR048748-02
Application #
6641329
Study Section
Special Emphasis Panel (ZAR1-AAA-C (J2))
Program Officer
Lester, Gayle E
Project Start
2002-08-01
Project End
2007-07-31
Budget Start
2003-08-01
Budget End
2004-07-31
Support Year
2
Fiscal Year
2003
Total Cost
$280,041
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Chang, A H; Chmiel, J S; Almagor, O et al. (2016) Association of baseline knee sagittal dynamic joint stiffness during gait and 2-year patellofemoral cartilage damage worsening in knee osteoarthritis. Osteoarthritis Cartilage :
Sharma, Leena; Chmiel, Joan S; Almagor, Orit et al. (2015) Knee Instability and Basic and Advanced Function Decline in Knee Osteoarthritis. Arthritis Care Res (Hoboken) 67:1095-102
Chang, A H; Moisio, K C; Chmiel, J S et al. (2015) External knee adduction and flexion moments during gait and medial tibiofemoral disease progression in knee osteoarthritis. Osteoarthritis Cartilage 23:1099-106
Rayahin, Jamie E; Chmiel, Joan S; Hayes, Karen W et al. (2014) Factors associated with pain experience outcome in knee osteoarthritis. Arthritis Care Res (Hoboken) 66:1828-35
Chang, A H; Chmiel, J S; Moisio, K C et al. (2013) Varus thrust and knee frontal plane dynamic motion in persons with knee osteoarthritis. Osteoarthritis Cartilage 21:1668-73
Sharma, Leena; Chmiel, Joan S; Almagor, Orit et al. (2013) The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study. Ann Rheum Dis 72:235-40
Lee, Jungwha; Song, Jing; Hootman, Jennifer M et al. (2013) Obesity and other modifiable factors for physical inactivity measured by accelerometer in adults with knee osteoarthritis. Arthritis Care Res (Hoboken) 65:53-61
Wise, Barton L; Niu, Jingbo; Yang, Mei et al. (2012) Patterns of compartment involvement in tibiofemoral osteoarthritis in men and women and in whites and African Americans. Arthritis Care Res (Hoboken) 64:847-52
Colbert, Carmelita J; Song, Jing; Dunlop, Dorothy et al. (2012) Knee confidence as it relates to physical function outcome in persons with or at high risk of knee osteoarthritis in the osteoarthritis initiative. Arthritis Rheum 64:1437-46
Gross, K Douglas; Niu, Jingbo; Stefanik, Joshua J et al. (2012) Breaking the Law of Valgus: the surprising and unexplained prevalence of medial patellofemoral cartilage damage. Ann Rheum Dis 71:1827-32

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