Abstract

OVERALL OBJECTIVES: The overall objective of this project is to investigate the causal association between human cytomegalovirus (human CMV) and various human malignancies, especially the virus and cell interactions that might bear upon the mechanism of herpes virus oncogenesis. GOALS SET FOR CURRENT YEAR: 1. To continue the effort in the detection of the existence of human CMV DNA genome in various cancer tissues. 2. To establish the recombinant DNA library for various CMV DNA fragments. 3. To continue the effort in searching for CMV DNA which is responsible for viral oncogenesis. 4. To compare the biological characteristics of various CMV strains isolated from tumor and various clinical manifestations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA021773-08
Application #
3165633
Study Section
Experimental Virology Study Section (EVR)
Project Start
1979-06-01
Project End
1987-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
8
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599