Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA049866-07
Application #
2093491
Study Section
Experimental Virology Study Section (EVR)
Project Start
1989-05-01
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Garcia, Andres J; Schwarzbauer, Jean E; Boettiger, David (2002) Distinct activation states of alpha5beta1 integrin show differential binding to RGD and synergy domains of fibronectin. Biochemistry 41:9063-9
Boettiger, D; Huber, F; Lynch, L et al. (2001) Activation of alpha(v)beta3-vitronectin binding is a multistage process in which increases in bond strength are dependent on Y747 and Y759 in the cytoplasmic domain of beta3. Mol Biol Cell 12:1227-37
Garcia, A J; Boettiger, D (1999) Integrin-fibronectin interactions at the cell-material interface: initial integrin binding and signaling. Biomaterials 20:2427-33
Garcia, A J; Vega, M D; Boettiger, D (1999) Modulation of cell proliferation and differentiation through substrate-dependent changes in fibronectin conformation. Mol Biol Cell 10:785-98
Garcia, A J; Huber, F; Boettiger, D (1998) Force required to break alpha5beta1 integrin-fibronectin bonds in intact adherent cells is sensitive to integrin activation state. J Biol Chem 273:10988-93
Shih, D T; Boettiger, D; Buck, C A (1997) Epitopes of adhesion-perturbing monoclonal antibodies map within a predicted alpha-helical domain of the integrin beta 1 subunit. J Cell Sci 110 ( Pt 20):2619-28
Boettiger, D; Enomoto-Iwamoto, M; Yoon, H Y et al. (1995) Regulation of integrin alpha 5 beta 1 affinity during myogenic differentiation. Dev Biol 169:261-72
Yoon, H; Boettiger, D (1994) Expression of v-src alters the expression of myogenic regulatory factor genes. Oncogene 9:801-7
Enomoto, M; Leboy, P S; Menko, A S et al. (1993) Beta 1 integrins mediate chondrocyte interaction with type I collagen, type II collagen, and fibronectin. Exp Cell Res 205:276-85
Enomoto, M I; Boettiger, D; Menko, A S (1993) Alpha 5 integrin is a critical component of adhesion plaques in myogenesis. Dev Biol 155:180-97

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