This application is a competing renewal. The original project concerned new fast magnetic resonance imaging (MRI) techniques for improved diagnosis of abdominal tumors. Significant progress was made in developing several fast-scan methods that produce high-quality T2-weighted abdominal images in a breath-hold. The focus of this competing renewal is on new MR methods that take the next step beyond tumor detection---the guidance of tumor biopsies and other interventional procedures using MR. The project title has been modified to reflect this change in focus.
The aims of this project are to 1) design and implement a real-time, interactive (RTI) MRI system tailored for interventional procedures, 2) develop and integrate into the RTI system new sequences that provide useful image contrast for interventional procedures; and 3) evaluate this new MR interventional system on phantoms and patients. The research plan includes substantial technical development of a versatile RTI MRI platform, studies of improved MR acquisition methods (e.g., steady-state free precession, fast spin echo, and color flow), and systematic tests to validate the performance of the resultant system. A research team with extensive technical and clinical expertise has been assembled for this project. This expertise, along with the state-of-the-art scanners available, make Stanford University an ideal environment to carry out this project.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project (R01)
Project #
Application #
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Farahani, Keyvan
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Stanford University
Engineering (All Types)
Schools of Engineering
United States
Zip Code
Vigen, Karl K; Jarrard, Jerry; Rieke, Viola et al. (2006) In vivo porcine liver radiofrequency ablation with simultaneous MR temperature imaging. J Magn Reson Imaging 23:578-84
Hargreaves, Brian A; Cunningham, Charles H; Nishimura, Dwight G et al. (2004) Variable-rate selective excitation for rapid MRI sequences. Magn Reson Med 52:590-7
Hargreaves, Brian A; Nishimura, Dwight G; Conolly, Steven M (2004) Time-optimal multidimensional gradient waveform design for rapid imaging. Magn Reson Med 51:81-92
Rieke, Viola; Vigen, Karl K; Sommer, Graham et al. (2004) Referenceless PRF shift thermometry. Magn Reson Med 51:1223-31
Miller, Karla L; Pauly, John M (2003) Nonlinear phase correction for navigated diffusion imaging. Magn Reson Med 50:343-53
Hargreaves, Brian A; Gold, Garry E; Beaulieu, Christopher F et al. (2003) Comparison of new sequences for high-resolution cartilage imaging. Magn Reson Med 49:700-9
Vigen, Karl K; Daniel, Bruce L; Pauly, John M et al. (2003) Triggered, navigated, multi-baseline method for proton resonance frequency temperature mapping with respiratory motion. Magn Reson Med 50:1003-10
Hargreaves, Brian A; Vasanawala, Shreyas S; Nayak, Krishna S et al. (2003) Fat-suppressed steady-state free precession imaging using phase detection. Magn Reson Med 50:210-3
Rivas, Pedro A; Nayak, Krishna S; Scott, Greig C et al. (2002) In vivo real-time intravascular MRI. J Cardiovasc Magn Reson 4:223-32
Hargreaves, B A; Vasanawala, S S; Pauly, J M et al. (2001) Characterization and reduction of the transient response in steady-state MR imaging. Magn Reson Med 46:149-58

Showing the most recent 10 out of 24 publications