Ras family GTPases are critical components of cell regulatory systems that control proliferation, differentiation, and cell survival. Inappropriate regulation of these systems directly contributes to initiation and progression of human cancer. This proposal is directed at increasing our understanding of the composition, organization, and function of cell regulatory networks engaged by Ras family GTPases. Our focus is on the dominant effector pathways that mediate oncogenic Ras-induced cell transformation.
Our specific aims are 1) revealing the molecular basis of the contribution of Ral GTPases to support of human tumor cell proliferation and survival;2) assessing the role of two candidate Ras effectors in limiting cellular responses to mitogenic signals;and 3) defining the contribution of scaffolding proteins to the generation of signal fidelity on the ERK1/2 MAP kinase cascade..

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA071443-14
Application #
7749575
Study Section
Cellular Signaling and Dynamics Study Section (CSD)
Program Officer
Watson, Joanna M
Project Start
1996-08-15
Project End
2011-06-30
Budget Start
2010-01-01
Budget End
2011-06-30
Support Year
14
Fiscal Year
2010
Total Cost
$261,370
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
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