Women who are diagnosed with ovarian cancer typically undergo an aggressive surgical and chemotherapy region which has an uncertain outcome. Mortality rates for this disease are high, as the chemotherapy regimen which has an uncertain outcome. Mortality rates for this disease are high, as are the rates for recurrence. Women undergoing treatment for this disease are subject to a large number of stresses. Despite the significant threat to life and bodily integrity these patients may endure, relatively few empirical studies have determined whether psychological interventions an improve ovarian cancer patients' emotional and social functioning. The goal of this research is to test two psychological interventions designed to bolster quality of life during and after treatment for ovarian cancer. The proposed study is a controlled clinical trial with three experimental conditions: non-directive supportive therapy, coping and communication skills therapy, and a standard care control group. Three hundred fifty eight women, recently diagnosed with Stage I to III ovarian cancer, will be randomly assigned to either a seven session coping and communication skill intervention, a seven session non-directive supportive therapy condition, or standard psychosocial care. The coping and communication skills intervention will assist patients in using adaptive cognitive processing/coping (emotional approach, positive reappraisal and growth, finding meaning) and learning communication skills to obtain more support from others. The non-directive supportive therapy intervention will focus on allowing the patient to ventilate and work through emotions she is experiencing. The intervention methods are based on cognitive processing theories of traumatic events and our prior work. We predict that both interventions will result in less distress in the short-term, the oping and communication skills intervention will result in more benefit in the long-term, because the patients are taught skills to enhance their cognitive and social processing of cancer within their existing social network. Patients will be assessed using questionnaire methods pre- and post-intervention, and at 9-month post-intervention follow-up.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA085566-05
Application #
6767547
Study Section
Special Emphasis Panel (ZRG1-RPHB-3 (01))
Program Officer
Jeffery, Diana D
Project Start
2000-08-01
Project End
2007-07-31
Budget Start
2004-08-01
Budget End
2007-07-31
Support Year
5
Fiscal Year
2004
Total Cost
$488,503
Indirect Cost
Name
Fox Chase Cancer Center
Department
Type
DUNS #
073724262
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
Gonzalez, Brian D; Manne, Sharon L; Stapleton, Jerod et al. (2017) Quality of life trajectories after diagnosis of gynecologic cancer: a theoretically based approach. Support Care Cancer 25:589-598
Manne, Sharon L; Virtue, Shannon Myers; Ozga, Melissa et al. (2017) A comparison of two psychological interventions for newly-diagnosed gynecological cancer patients. Gynecol Oncol 144:354-362
Manne, Sharon L; Myers-Virtue, Shannon; Kashy, Deborah A et al. (2016) Therapy processes, progress, and outcomes for 2 therapies for gynecological cancer patients. Psychooncology :
Manne, Sharon L; Myers-Virtue, Shannon; Kashy, Deborah et al. (2015) Resilience, Positive Coping, and Quality of Life Among Women Newly Diagnosed With Gynecological Cancers. Cancer Nurs 38:375-82
Myers Virtue, Shannon; Manne, Sharon L; Darabos, Kathleen et al. (2015) Emotion episodes during psychotherapy sessions among women newly diagnosed with gynecological cancers. Psychooncology 24:1189-96
Manne, Sharon; Myers, Shannon; Ozga, Melissa et al. (2014) Holding back sharing concerns, dispositional emotional expressivity, perceived unsupportive responses and distress among women newly diagnosed with gynecological cancers. Gen Hosp Psychiatry 36:81-7
Myers Virtue, Shannon; Manne, Sharon L; Ozga, Melissa et al. (2014) Cancer-related concerns among women with a new diagnosis of gynecological cancer: an exploration of age group differences. Int J Gynecol Cancer 24:165-71
Myers, Shannon B; Manne, Sharon L; Kissane, David W et al. (2013) Social-cognitive processes associated with fear of recurrence among women newly diagnosed with gynecological cancers. Gynecol Oncol 128:120-7
Manne, Sharon L; Kashy, Deborah A; Rubin, Stephen et al. (2012) Therapist and patient perceptions of alliance and progress in psychological therapy for women diagnosed with gynecological cancers. J Consult Clin Psychol 80:800-810
Manne, Sharon; Winkel, Gary; Zaider, Talia et al. (2010) Therapy processes and outcomes of psychological interventions for women diagnosed with gynecological cancers: A test of the generic process model of psychotherapy. J Consult Clin Psychol 78:236-48

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