Studies performed over the past decade give evidence that for lung cancer, increased radiotherapy dose will lead to better local control and survival. Further studies show that the main lung cancer radiotherapy side effect, pneumonitis, can be significantly reduced by lowering the dose delivered to healthy lung tissue. Balancing these conflicting goals is difficult, especially since a lung tumor moves on average 1.5-2 cm with respiratory motion. This project aims to develop and implement a technique entitled 4D IMRT (4-Dimensional Intensity Modulated Radiation Therapy). The 4th dimension, or time, component of the technique means that the tumor motion is accounted for during the imaging, planning and delivery of radiation. Tracking the tumor with the radiation beam during treatment delivery allows a reduction in beam margin and consequently a reduction in the volume of healthy tissue exposed to a high dose. The IMRT component of the technique allows us to give a sufficiently high dose to the tumor and an acceptably low dose to the healthy lung tissue. We will investigate the hypotheses that 4D IMRT will lead to: 1. improved treatment plans compared with conventional IMRT, 2. reduced volumes of normal tissue exposed to injurious doses compared with conventional IMRT, 3. reduced delivery time compared with respiration-gated IMRT, 4. wider applicability than breath-hold techniques, and 5. higher accuracy in delivered dose distributions compared with conventional and respiration-gated techniques.Though the studies here will concentrate mainly on lung cancer, 4D IMRT is applicable to all sites affected by respiratory motion, including breast and liver cancer, and even cervix and prostate cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA093626-02
Application #
6608196
Study Section
Radiation Study Section (RAD)
Program Officer
Deye, James
Project Start
2002-07-15
Project End
2007-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
2
Fiscal Year
2003
Total Cost
$285,225
Indirect Cost
Name
Virginia Commonwealth University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
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