Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA099194-02
Application #
6694025
Study Section
Special Emphasis Panel (ZRG1-CAMP (03))
Program Officer
Okano, Paul
Project Start
2003-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$335,295
Indirect Cost
Name
New York University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
041968306
City
New York
State
NY
Country
United States
Zip Code
10012
Cohen, Isadora S; Bar, Carmit; Paz-Elizur, Tamar et al. (2015) DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes. Nucleic Acids Res 43:1637-45
Izhar, Lior; Ziv, Omer; Cohen, Isadora S et al. (2013) Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells. Proc Natl Acad Sci U S A 110:E1462-9
Cai, Yuqin; Zheng, Han; Ding, Shuang et al. (2013) Free energy profiles of base flipping in intercalative polycyclic aromatic hydrocarbon-damaged DNA duplexes: energetic and structural relationships to nucleotide excision repair susceptibility. Chem Res Toxicol 26:1115-25
Kropachev, Konstantin; Kolbanovskiy, Marina; Liu, Zhi et al. (2013) Adenine-DNA adducts derived from the highly tumorigenic Dibenzo[a,l]pyrene are resistant to nucleotide excision repair while guanine adducts are not. Chem Res Toxicol 26:783-93
Diamant, Noam; Hendel, Ayal; Vered, Ilan et al. (2012) DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity. Nucleic Acids Res 40:170-80
Mu, Hong; Kropachev, Konstantin; Wang, Lihua et al. (2012) Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies. Nucleic Acids Res 40:9675-90
Lior-Hoffmann, Lee; Wang, Lihua; Wang, Shenglong et al. (2012) Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase ? elucidates error-free bypass of a bulky DNA lesion. Nucleic Acids Res 40:9193-205
Minero, Antonio S; Lukashevich, Olga V; Cherepanova, Natalia A et al. (2012) Probing murine methyltransfease Dnmt3a interactions with benzo[a]pyrene-modified DNA by fluorescence methods. FEBS J 279:3965-80
Skosareva, Lidia V; Lebedeva, Natalia A; Rechkunova, Nadejda I et al. (2012) Human DNA polymerase ? catalyzes lesion bypass across benzo[a]pyrene-derived DNA adduct during base excision repair. DNA Repair (Amst) 11:367-73
Tang, Yijin; Liu, Zhi; Ding, Shuang et al. (2012) Nuclear magnetic resonance solution structure of an N(2)-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: intercalation from the minor groove with ruptured Watson-Crick base pairing. Biochemistry 51:9751-62

Showing the most recent 10 out of 54 publications