PUBLIC HEALTH STATEMENT Prostate cancer is a major cause of morbidity and mortality among men in the United States. In this proposal, we aim to develop novel non-toxic complementary treatments aimed at slowing prostate cancer progression: dietary modification and phytopharmaceuticals. If these pre-clinical studies are successful, this will lay a solid foundation for future clinical studies among men with prostate cancer, which eventually stand the possibility of radically altering and improving care for men with prostate cancer.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project (R01)
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Chemo/Dietary Prevention Study Section (CDP)
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Kim, Young S
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Duke University
Schools of Medicine
United States
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Allott, Emma H; Howard, Lauren E; Cooperberg, Matthew R et al. (2014) Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. BJU Int 114:661-6
Allott, Emma H; Howard, Lauren E; Song, Hai-Jun et al. (2014) Racial differences in adipose tissue distribution and risk of aggressive prostate cancer among men undergoing radiotherapy. Cancer Epidemiol Biomarkers Prev 23:2404-12
Osmond, Gregory W; Masko, Elizabeth M; Tyler, Douglas S et al. (2013) In vitro and in vivo evaluation of resveratrol and 3,5-dihydroxy-4'-acetoxy-trans-stilbene in the treatment of human prostate carcinoma and melanoma. J Surg Res 179:e141-8
Caso, Jorge; Masko, Elizabeth M; Ii, Jean A Thomas et al. (2013) The effect of carbohydrate restriction on prostate cancer tumor growth in a castrate mouse xenograft model. Prostate 73:449-54
Lloyd, J C; Masko, E M; Wu, C et al. (2013) Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expression. Prostate Cancer Prostatic Dis 16:285-91
Allott, E H; Abern, M R; Gerber, L et al. (2013) Metformin does not affect risk of biochemical recurrence following radical prostatectomy: results from the SEARCH database. Prostate Cancer Prostatic Dis 16:391-7
Selim, Maria A; Burchette, James L; Bowers, Edith V et al. (2011) Changes in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survival. Melanoma Res 21:323-34
Misra, U K; Mowery, Y M; Gawdi, G et al. (2011) Loss of cell surface TFII-I promotes apoptosis in prostate cancer cells stimulated with activated ýýýýý -macroglobulin. J Cell Biochem 112:1685-95
Misra, Uma K; Payne, Sturgis; Pizzo, Salvatore V (2011) Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen. J Biol Chem 286:1248-59
Misra, U K; Pizzo, S V (2010) Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78. Apoptosis 15:173-82

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