Cancer and its treatment are associated with considerable distress, impaired quality of life (QOL), poor mental health, and reduced physical function. This is particularly true for women with breast cancer who receive multimodal treatment over an extended period of time. Many women undergo surgery and chemotherapy, which are often followed by radiotherapy. It is important to develop programs that can help ameliorate the treatment-related morbidity that accumulates over time for women with breast cancer. Furthermore, given the stressful time demands posed by radiotherapy treatment (patients typically receive treatment 5-days per week for 6 weeks) it is crucial that programs be easily incorporated into the treatment schedule. Research suggests that stress-reduction programs tailored to the cancer setting may help patients cope with the acute effects of treatment and improve QOL after treatment. Yoga, an ancient Indian science, incorporates stress-reduction techniques including regulated breathing, visual imagery, meditation, and various gentle stretching postures. Yoga may be particularly useful for women with breast cancer after surgery and while undergoing radiation treatment because of the stress management and relaxation techniques and the gentle stretching that should facilitate recovery. Preliminary studies found yoga is useful for women with breast cancer undergoing radiotherapy. Integrating a yoga program into the treatment regimen of women undergoing radiotherapy for breast cancer makes participation in the program easy and compliance has been high. We will determine the efficacy of implementing a yoga program for patients with breast cancer as an adjuvant to their radiotherapy. Patients with breast cancer who are undergoing radiotherapy will be randomly assigned to one of three groups: a yoga group, a stretching/relaxation group, or a waitlist control group. Participants in the two intervention groups will attend sessions 3 days/week throughout their 6-week radiotherapy schedule. Measures will be obtained prior to randomization, midway through radiotherapy, during the last week of radiotherapy, and 1 and 3, 6 and 12 months after the end of radiotherapy. We will examine indices of QOL, fatigue, sleep disturbances, mental health, cost- effectiveness analysis, work and/or home productivity, and cortisol rhythmicity. We hypothesize that the yoga program will help facilitate recovery and alleviate the physiological and psychological side effects experienced by patients who are currently receiving radiotherapy.

Public Health Relevance

The proposed study will examine efficacy of incorporating a Yoga program alongside radiotherapy for women with breast cancer. If we find that the Yoga program facilitates recovery and alleviates the psychological and physiological side effects experienced by women undergoing radiotherapy, then this type of program can be incorporated into the treatment plan as the standard of care. Future research could examine individual preferences for different types of mind-body or physical activity programs incorporated in the treatment plan to help with recovery.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA138800-03
Application #
8298581
Study Section
Behavioral Medicine, Interventions and Outcomes Study Section (BMIO)
Program Officer
O'Mara, Ann M
Project Start
2010-04-01
Project End
2016-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
3
Fiscal Year
2012
Total Cost
$769,790
Indirect Cost
$282,581
Name
University of Texas MD Anderson Cancer Center
Department
Type
Schools of Medicine
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Milbury, Kathrin; Kavanagh, April; Meng, Zhiqiang et al. (2017) Depressive symptoms and positive affect in Chinese and United States breast cancer survivors: a cross-cultural comparison. Support Care Cancer 25:2103-2109
Ratcliff, Chelsea G; Milbury, Kathrin; Chandwani, Kavita D et al. (2016) Examining Mediators and Moderators of Yoga for Women With Breast Cancer Undergoing Radiotherapy. Integr Cancer Ther 15:250-62
Chandwani, Kavita D; Perkins, George; Nagendra, Hongasandra Ramarao et al. (2014) Randomized, controlled trial of yoga in women with breast cancer undergoing radiotherapy. J Clin Oncol 32:1058-65