We propose to develop designs for phase I trials conducted in heterogeneous groups of patients. Phase I trials in oncology are meant to establish the 'maximally tolerated dose' (MTD), the highest dose that can be administered without excessive side effects. In many studies, the group structure is not used in the design. The resulting recommended dose is weighted in favor of the dose for the most frequently occurring group, effectively moving away from 'personalized' dosing for patients. At present, the most common way to include the group structure as part of the design is to conduct a separate phase I trial within each group. This can be inefficient, requiring a large number of patients, and can lead to dose recommendations that run counter to what is known clinically about the groups. In this proposal, we will develop efficient designs for phase I trials in groups that build from our previous work in designs for combinations of agent. Our goal is to develop efficient and more accurate designs for phase I trials in groups of patients that can lead to improved care across the entire range of cancers and cancer therapies.

Public Health Relevance

Dose-finding trials of new agents in oncology are often done in groups of patients, where the safe dose varies by group. In many of these studies, it is known before the start of the study that the groups are ordered, meaning that for any fixed dose of the agent, the groups can be ordered in terms of the probability that a patient will experience a severe side effect. In some cases, the grouping is ignored in the design of the trial, and a single dose is recommended for all the patients. The effect of this is to weigh the recommended dose in favor of the most frequent group, and potentially expose patients in other groups to overly toxic doses or sub-optimal therapies. In studies that use the group information, the most common design is to run separate studies in each group. This can be inefficient and can lead to recommended doses that run counter to what is known about the ordering of the groups. In this proposal, we will develop methods that allow us to use the information from all the patients in all the groups to estimate the safe dose within each group. The goal is to have efficient designs that 'personalize' doses within groups.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA142859-07
Application #
9242508
Study Section
Cancer Biomarkers Study Section (CBSS)
Program Officer
Witherspoon, Kim
Project Start
2010-07-01
Project End
2019-04-30
Budget Start
2017-05-01
Budget End
2019-04-30
Support Year
7
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Virginia
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Conaway, Mark R; Petroni, Gina R (2018) The Impact of Early-Phase Trial Design in the Drug Development Process. Clin Cancer Res :
Wages, Nolan A; Petroni, Gina R (2018) A web tool for designing and conducting phase I trials using the continual reassessment method. BMC Cancer 18:133
Wages, Nolan A; Conaway, Mark R (2018) Revisiting isotonic phase I design in the era of model-assisted dose-finding. Clin Trials 15:524-529
Iasonos, Alexia; O'Quigley, John (2017) Phase I Designs that Allow for Uncertainty in the Attribution of Adverse Events. J R Stat Soc Ser C Appl Stat 66:1015-1030
Conaway, Mark (2017) Isotonic designs for phase I trials in partially ordered groups. Clin Trials 14:491-498
Conaway, Mark R; Wages, Nolan A (2017) Designs for phase I trials in ordered groups. Stat Med 36:254-265
Wages, Nolan A; Varhegyi, Nikole (2017) A web application for evaluating Phase I methods using a non-parametric optimal benchmark. Clin Trials 14:553-557
Wages, N A; Slingluff Jr, C L; Petroni, G R (2017) Statistical controversies in clinical research: early-phase adaptive design for combination immunotherapies. Ann Oncol 28:696-701
Petroni, Gina R; Wages, Nolan A; Paux, Gautier et al. (2017) Implementation of adaptive methods in early-phase clinical trials. Stat Med 36:215-224
Iasonos, Alexia; O'Quigley, John (2017) Sequential monitoring of Phase I dose expansion cohorts. Stat Med 36:204-214

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