Cancer chemotherapy-induced peripheral neuropathy (CIN) is the most prevalent neurological complication of cancer treatment. It is a major side effect of the most frequently administered chemotherapy (CTX) drugs. While epidemiologic studies are limited, clinical experience suggests that CIN occurs in a large percentage of patients and has a significant impact on patients'ability to function and quality of life. In addition, effective treatments for CIN are not available at the present time. This study will be conducted in two parts. In Part 1, using a sample of patients with (n=400) and without (n=200) CIN who have completed CTX, differences in phenotypic (i.e., sensory characteristics, motor characteristics, mood, concurrent symptoms, balance, quality of life) and genotypic characteristics (i.e., candidate gene studies) will be evaluated. In Part 2, based on recent work from our group that demonstrated the efficacy of photon stimulation in improving sensation and quality of life in patients with painful diabetic peripheral neuropathy, we will conduct a pilot study to determine effect sizes for the effects of photon stimulation compared to placebo in improving light touch sensation, pain intensity, and pain qualities in oncology patients with CIN who have completed CTX. In addition, we will determine the feasibility of the treatment protocol and the safety of photon stimulation in patients with CIN. Patients will be treated with eight photon stimulation or placebo treatments over a period of 14 days. Subjective and objective measures will be done at baseline and prior to each of the treatments on days 2, 4, 6, and 8. Data from this pilot study will be used to determine if a large scale randomized clinical trial of photon stimulation is warranted for CIN.
|Kober, Kord M; Mazor, Melissa; Abrams, Gary et al. (2018) Phenotypic Characterization of Paclitaxel-Induced Peripheral Neuropathy in Cancer Survivors. J Pain Symptom Manage 56:908-919.e3|
|Miaskowski, Christine; Paul, Steven M; Mastick, Judy et al. (2018) Associations Between Perceived Stress and Chemotherapy-Induced Peripheral Neuropathy and Otoxicity in Adult Cancer Survivors. J Pain Symptom Manage 56:88-97|
|Miaskowski, Christine; Paul, Steven M; Mastick, Judy et al. (2018) Hearing loss and tinnitus in survivors with chemotherapy-induced neuropathy. Eur J Oncol Nurs 32:1-11|
|Miaskowski, Christine; Mastick, Judy; Paul, Steven M et al. (2018) Impact of chemotherapy-induced neurotoxicities on adult cancer survivors' symptom burden and quality of life. J Cancer Surviv 12:234-245|
|Miaskowski, Christine; Mastick, Judy; Paul, Steven M et al. (2017) Chemotherapy-Induced Neuropathy in Cancer Survivors. J Pain Symptom Manage 54:204-218.e2|
|Kelley, Robin K; Atreya, Chloe; Venook, Alan P et al. (2012) Predictive biomarkers in advance of a companion drug: ahead of their time? J Natl Compr Canc Netw 10:303-9|