The Oral Microbiome and Upper Aerodigestive Squamous Cell Cancer We propose an innovative study to examine whether the oral microbiome is associated with risk of upper aerodigestive squamous cell cancers (UADSCC: oral, pharyngeal, laryngeal and esophageal squamous cell cancers). Our research team has developed a unique capability to conduct microbiome research (NIH grant: 1UH2CA140233, 5R01AI063477), have recently reported the relationship of foregut microbiome profiles with esophageal premalignant conditions (Yang et al., Gastroenterology, 2009), and now have preliminary data showing an association between the oral microbiome and oral cancer risk. Tobacco and alcohol are the major known risk factors for UADSCC. We hypothesize that microorganisms in the oral cavity potentiate UADSC carcinogenesis, potentially related to alcohol and tobacco use. The goals of our study are to relate the oral microbiome to UADSCC risk and to identify the impact of alcohol and tobacco use on the oral microbiome, in the first epidemiologic investigation of this topic. We plan to characterize, in 140 UADSCC cases and 420 controls, all common oral microbial species (including non-culturables) by sequencing the 16S rRNA microbial genes in oral wash samples. Because UADSCC disease and treatment status can alter oral microbial profiles (reverse causation), we are using a prospective research design, in the ACS and PLCO cohorts in which oral wash samples were collected prior to disease development. Our study will identifying oral bacterial profiles related to UADSCC risk, providing direct leads to implement prophylactic interventions as critical adjuncts to alcohol and tobacco control programs in UADSCC prevention.

Public Health Relevance

The proposed project is an innovative study to examine whether the oral microbiome is associated with risk of upper aerodigestive cell cancers (UADSCC: oral, pharyngeal, laryngeal and esophageal squamous cell cancers). The goals of our study are to relate the oral microbiome to UADSCC risk and to identify the impact of alcohol and tobacco use on the oral microbiome, in the first epidemiologic investigation of this topic.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA159036-03S1
Application #
8761369
Study Section
Epidemiology of Cancer Study Section (EPIC)
Program Officer
Zhu, Claire
Project Start
2014-01-15
Project End
2016-01-14
Budget Start
2014-01-15
Budget End
2016-01-14
Support Year
3
Fiscal Year
2014
Total Cost
$276,844
Indirect Cost
$113,514
Name
New York University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
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Xu, Weisheng; Yang, Liying; Lee, Peng et al. (2014) Mini-review: perspective of the microbiome in the pathogenesis of urothelial carcinoma. Am J Clin Exp Urol 2:57-61
Baghdadi, Jonathan; Chaudhary, Noami; Pei, Zhiheng et al. (2014) Microbiome, innate immunity, and esophageal adenocarcinoma. Clin Lab Med 34:721-32
Yang, Liying; Chaudhary, Noami; Baghdadi, Jonathan et al. (2014) Microbiome in reflux disorders and esophageal adenocarcinoma. Cancer J 20:207-10
Cho, Margaret; Carter, Janell; Harari, Saul et al. (2014) The interrelationships of the gut microbiome and inflammation in colorectal carcinogenesis. Clin Lab Med 34:699-710
Goedert, James J; Sampson, Joshua N; Moore, Steven C et al. (2014) Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis 35:2089-96
Dominianni, C; Huang, W-Y; Berndt, S et al. (2013) Prospective study of the relationship between coffee and tea with colorectal cancer risk: the PLCO Cancer Screening Trial. Br J Cancer 109:1352-9
Ahn, Jiyoung; Chen, Calvin Y; Hayes, Richard B (2012) Oral microbiome and oral and gastrointestinal cancer risk. Cancer Causes Control 23:399-404
Yang, Liying; Francois, Fritz; Pei, Zhiheng (2012) Molecular pathways: pathogenesis and clinical implications of microbiome alteration in esophagitis and Barrett esophagus. Clin Cancer Res 18:2138-44
Ahn, Jiyoung; Segers, Stephanie; Hayes, Richard B (2012) Periodontal disease, Porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality. Carcinogenesis 33:1055-8

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