Abstract

A program of studies will continue an investigation of noradrenergic and dopaminergic action on neuronal circuits in the central nervous system. Functions of the noradrenergic projection system in the cerebellum, and cerebral cortex will be examined by employing microiontophoresis of drugs, physiological activation of visual, auditory input, stimulation of locus coeruleus and use of brain slice preparations of rat.
The aim will be to establish a basis for the examination of the potential interactions between the noradrenergic system and drugs of abuuse including d-amphetamine and cocaine. Similar studies will be conducted of unit activity in striatum. The proposed studies will continue exploration of the hypothesis that norepinephrine and dopamine exert a modulatory influence on synaptic efficacy, and act to regulate neuronal circuit gating functions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA002338-12
Application #
3207272
Study Section
Special Emphasis Panel (DABA)
Project Start
1979-05-01
Project End
1991-11-30
Budget Start
1990-12-01
Budget End
1991-11-30
Support Year
12
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

Chang, J-Y; Chen, L; Luo, F et al. (2002) Neuronal responses in the frontal cortico-basal ganglia system during delayed matching-to-sample task: ensemble recording in freely moving rats. Exp Brain Res 142:67-80
Chang, J Y; Janak, P H; Woodward, D J (2000) Neuronal and behavioral correlations in the medial prefrontal cortex and nucleus accumbens during cocaine self-administration by rats. Neuroscience 99:433-43
Woodward, D J; Chang, J Y; Janak, P et al. (2000) Activity patterns in mesolimbic regions in rats during operant tasks for reward. Prog Brain Res 126:303-22
Kampman, K M; Volpicelli, J R; Alterman, A I et al. (2000) Amantadine in the treatment of cocaine-dependent patients with severe withdrawal symptoms. Am J Psychiatry 157:2052-4
Woodward, D J; Chang, J Y; Janak, P et al. (1999) Mesolimbic neuronal activity across behavioral states. Ann N Y Acad Sci 877:91-112
Chang, J Y; Janak, P H; Woodward, D J (1998) Comparison of mesocorticolimbic neuronal responses during cocaine and heroin self-administration in freely moving rats. J Neurosci 18:3098-115
Chang, J Y; Sawyer, S F; Paris, J M et al. (1997) Single neuronal responses in medial prefrontal cortex during cocaine self-administration in freely moving rats. Synapse 26:22-35
Chang, J Y; Zhang, L; Janak, P H et al. (1997) Neuronal responses in prefrontal cortex and nucleus accumbens during heroin self-administration in freely moving rats. Brain Res 754:12-20
Chang, J Y; Paris, J M; Sawyer, S F et al. (1996) Neuronal spike activity in rat nucleus accumbens during cocaine self-administration under different fixed-ratio schedules. Neuroscience 74:483-97
Lee, R S; Smith, S S; Chapin, J K et al. (1995) Effects of systemic and local ethanol on responses of rat cerebellar Purkinje neurons to iontophoretically applied gamma-aminobutyric acid. Brain Res 687:1-11

Showing the most recent 10 out of 31 publications