This project is designed to investigate the effects of drugs of abuse on affective responses to stimuli with positive or negative emotional valence. The studies explore the hypothesis that drugs modulate responses to affective stimuli, and that these effects, in turn, influence the drugs'subjective or reinforcing effects. We will study bidirectional interactions between acute effects of stimulants, alcohol and cannabinoids on affective responses. The studies focus in particular on affective responses to stimuli with social content, to investigate the idea that drugs influence the perception and valence of social stimuli. We will assess the effects of drugs on responses to positive or negative visual images, including images with social or nonsocial content. In addition, we will investigate drug the effects of drugs in real-life positive or negative social situations. In all studies we will compare these emotional responses in men and women. This innovative approach bridges the area of neuropsychopharmacology with affective neuroscience, and if successful, will extend our understanding of the processes that lead to compulsive drug-seeking behavior.

Public Health Relevance

It is usually thought that people use and abuse drugs because the drugs produce feelings of wellbeing, but drugs also may influence behavior by making emotionally positive stimuli or events appear to be more positive, or by making negative stimuli or events less negative. We will investigate the direct effects of drugs on emotional responses, using both pleasant and unpleasant stimuli, and social and nonsocial stimuli. We will study social content because social behavior and drug rewards share some of the same brain circuits, and we will compare the drugs'effects on emotional responses in men and women because there may be sex differences in these effects.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
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Study Section
Biobehavioral Regulation, Learning and Ethology Study Section (BRLE)
Program Officer
Kautz, Mary A
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University of Chicago
Schools of Medicine
United States
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van den Berg, Stéphanie M; de Moor, Marleen H M; Verweij, Karin J H et al. (2016) Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. Behav Genet 46:170-82
Smith, Christopher T; Weafer, Jessica; Cowan, Ronald L et al. (2016) Individual differences in timing of peak positive subjective responses to d-amphetamine: Relationship to pharmacokinetics and physiology. J Psychopharmacol 30:330-43
Miller, Melissa A; Bershad, Anya; King, Andrea C et al. (2016) Intranasal oxytocin dampens cue-elicited cigarette craving in daily smokers: a pilot study. Behav Pharmacol 27:697-703
Bershad, Anya K; Seiden, Jacob A; de Wit, Harriet (2016) Effects of buprenorphine on responses to social stimuli in healthy adults. Psychoneuroendocrinology 63:43-9
Bershad, Anya K; Weafer, Jessica J; Kirkpatrick, Matthew G et al. (2016) Oxytocin receptor gene variation predicts subjective responses to MDMA. Soc Neurosci 11:592-9
Weafer, Jessica; Gallo, David A; de Wit, Harriet (2016) Acute Effects of Alcohol on Encoding and Consolidation of Memory for Emotional Stimuli. J Stud Alcohol Drugs 77:86-94
Wardle, Margaret C; Bershad, Anya K; de Wit, Harriet (2016) Naltrexone alters the processing of social and emotional stimuli in healthy adults. Soc Neurosci 11:579-91
Weafer, Jessica; Gallo, David A; de Wit, Harriet (2016) Effect of Alcohol on Encoding and Consolidation of Memory for Alcohol-Related Images. Alcohol Clin Exp Res 40:1540-7
Mayo, Leah M; de Wit, Harriet (2016) Acquisition of Conditioned Responses to a Novel Alcohol-Paired Cue in Social Drinkers. J Stud Alcohol Drugs 77:317-26
Miller, Melissa A; Bershad, Anya K; de Wit, Harriet (2015) Drug effects on responses to emotional facial expressions: recent findings. Behav Pharmacol 26:571-9

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