The Risk Factors project has studied the very large HIV epidemic among injecting drug users (IDUs) in New York City from 1978 (using stored sera) and the very large HIV epidemic among non-injecting heroin and cocaine drug users (NIDUs) since 1995. In our current research, we have demonstrated a dramatic reduction in HIV transmission among IDUs, but also a substantial increase in HIV among NIDUS. (HIV prevalence has doubled among NIDUs in NYC over the last decade). Herpes simplex virus-2 (HSV-2) is strongly associated with HIV transmission, and we have identified prevalence HSV-2 as a major factor associated with HIV transmission among NIDUs in NYC.
The specific aims of the proposed research include: 1) Monitoring risk behavior, HIV prevalence and incidence and service utilization in the continuing evolution of the HIV epidemic among NIDUs and IDUs in New York City. 2) Quantifying the long-term population-level relationships between HIV and HSV-2 infections among heroin and cocaine users in NYC, including testing the hypothesis that the strength of the association between HSV-2 and HIV increases over time. Recent intervention studies have dramatically increased the need for understanding HSV-2/HIV relationships. 3) Evaluating effects of the New York City Department of Health (NYC DOH) Condom Social Marketing campaign on sexual risk behaviors and HIV and HSV-2 infection among IDUs and NIDUs in NYC. 4) Monitoring patterns of sexual and injection related HIV transmission among IDUs in NYC. There are many linkages between NIDUs and IDUs in NYC. NIDUs and IDUs are best viewed as linked groups within a single population of heroin and cocaine users in NYC. A thorough understanding of sexual transmission among NIDUs requires an understanding of both injecting and sexual transmission among IDUs in the city. 5) Assess new patterns of racial/ethnic differences in HIV infection among NIDUs and IDUs. 6) Intervention development.
These aims will be accomplished through continuation of our studies of NIDUs and IDUs entering Beth Israel drug treatment programs in NYC. The proposed research will be the first study of the spread of HIV over time in a very large population of NIDUs, the first assessment of change in the relationship of HVS-2 to HIV over time among NIDUs, and the first assessment of the effects of a very large condom social marketing campaign on sexual risk behavior of NIDUs and IDUs.

Public Health Relevance

Sexual transmission of HIV among non-injecting drug users has become a major public health problem in the US. This study will generate an in-depth understanding of the largest HIV epidemic among NIDUs in the US.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA003574-30
Application #
8459511
Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Hartsock, Peter
Project Start
1994-09-10
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
30
Fiscal Year
2013
Total Cost
$619,905
Indirect Cost
$218,187
Name
Beth Israel Medical Center (New York)
Department
Type
DUNS #
075255364
City
New York
State
NY
Country
United States
Zip Code
10003
Jarlais, Don C Des; Arasteh, Kamyar; McKnight, Courtney et al. (2016) Providing ART to HIV Seropositive Persons Who Use Drugs: Progress in New York City, Prospects for ""Ending the Epidemic"". AIDS Behav 20:353-62
Elliott, Jennifer C; Hasin, Deborah S; Stohl, Malka et al. (2016) HIV, Hepatitis C, and Abstinence from Alcohol Among Injection and Non-injection Drug Users. AIDS Behav 20:548-54
Jõgeda, Ene-Ly; Avi, Radko; Pauskar, Merit et al. (2016) Human T-lymphotropic virus types 1 and 2 are rare among intravenous drug users in Eastern Europe. Infect Genet Evol 43:83-5
Des Jarlais, Don C; Arasteh, Kamyar; Feelemyer, Jonathan et al. (2016) Decline in Herpes Simplex Virus Type 2 Among Non-Injecting Heroin and Cocaine Users in New York City, 2005 to 2014: Prospects for Avoiding a Resurgence of Human Immunodeficiency Virus. Sex Transm Dis :
Des Jarlais, Don C; Kerr, Thomas; Carrieri, Patrizia et al. (2016) HIV infection among persons who inject drugs: ending old epidemics and addressing new outbreaks. AIDS 30:815-26
Des Jarlais, Don C; Arasteh, Kamyar; McKnight, Courtney et al. (2016) What happened to the HIV epidemic among non-injecting drug users in New York City? Addiction :
Des Jarlais, Don C; Carrieri, Patrizia (2016) HIV infection among persons who inject drugs: ending old epidemics and addressing new outbreaks: authors' reply. AIDS 30:1858-9
Jarlais, Don C Des; Arasteh, Kamyar; Feelemyer, Jonathan et al. (2016) From Long-Term Injecting to Long-Term Non-Injecting Heroin and Cocaine Use: The Persistence of Changed Drug Habits. J Subst Abuse Treat 71:48-53
Elliott, Jennifer C; Hasin, Deborah S; Des Jarlais, Don C (2016) Perceived risk for severe outcomes and drinking status among drug users with HIV and Hepatitis C Virus (HCV). Addict Behav 63:57-62
Campbell, Aimee N C; Des Jarlais, Don; Hannah, Cooper et al. (2016) Antiretroviral medication treatment for all HIV-infected individuals: a protocol using innovative multilevel methodologies to evaluate New York City's universal ART policy among problem substance users. BMC Health Serv Res 16:341

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